CAJ | 학술논문

目的：探讨腋窝淋巴结阴性浸润性乳腺癌不同分子分型的分布，临床病理特征以及和预后的关系。方法：回顾性分析183例该类乳腺癌患者的临床病理资料，对管腔上皮（Luminal）型、基底样（Basal-1ike）型和HER-2过表达（over-expression）型乳腺癌患者在年龄、肿瘤大小、临床分期和无瘤生存率（disease-free survival，DFS）、总生存率（overall survival，OS）方面进行统计分析。结果：不同分子亚型乳腺癌在年龄、肿瘤大小、临床分期方面无显著性差异。Luminal、Basal-like、HER-2过表达型的复发率分别为3.9%（4/102）、20.4%（10/49）、6.3%（2/32）（P=0.002）；死亡率分别为2.0%（2/102）、6.1%（3/49）、3.1%（1/32）（P>0.05）。Ka-plan-Meier分析显示Basal-like型的DFS最低（P=0.002），Basal-like型的OS较低（P=0.39）。Cox多因素比例风险模型分析显示分子亚型对DFS存在显著影响（P=0.001）。结论：在腋窝淋巴结阴性浸润性乳腺癌患者中，不同分子亚型在年龄、肿瘤大小及临床分期方面无显著性差异，Basal-like型预后最差，分子分型是其独立预后指标。
목적：탐토액와림파결음성침윤성유선암불동분자분형적분포，림상병리특정이급화예후적관계。방법：회고성분석183례해류유선암환자적림상병리자료，대관강상피（Luminal）형、기저양（Basal-1ike）형화HER-2과표체（over-expression）형유선암환자재년령、종류대소、림상분기화무류생존솔（disease-free survival，DFS）、총생존솔（overall survival，OS）방면진행통계분석。결과：불동분자아형유선암재년령、종류대소、림상분기방면무현저성차이。Luminal、Basal-like、HER-2과표체형적복발솔분별위3.9%（4/102）、20.4%（10/49）、6.3%（2/32）（P=0.002）；사망솔분별위2.0%（2/102）、6.1%（3/49）、3.1%（1/32）（P>0.05）。Ka-plan-Meier분석현시Basal-like형적DFS최저（P=0.002），Basal-like형적OS교저（P=0.39）。Cox다인소비례풍험모형분석현시분자아형대DFS존재현저영향（P=0.001）。결론：재액와림파결음성침윤성유선암환자중，불동분자아형재년령、종류대소급림상분기방면무현저성차이，Basal-like형예후최차，분자분형시기독립예후지표。
Objective:To analyze the distribution, clinico-pathologic features, and survival status of different subtypes in axillary lymph node-negative invasive breast cancer patients. Methods:In this study, data of 183 patients were included and retrospectively ana-lyzed in terms of age distribution, clinico-pathologic features, disease-free survival (DFS), and overall survival based on different sub-types (luminal, basal-like, and HER-2 over-expression). Results:No significant differences in age, tumor size, and TNM stage was ob-served among different subtypes. The relapse rates of luminal, basal-like, and HER-2 over-expression subtypes were 3.9% (4/102), 20.4% (10/49), and 6.3% (2/32), respectively (P=0.002). The death rates of luminal, basal-like, and HER-2 over-expression subtypes were 2.0%(2/102), 6.1%(3/49), and 3.1%(1/32), respectively (P>0.05). Kaplan-Meier analysis showed that the DFS of basal-like sub-type was much lower compared with that of the luminal and HER-2 over-expression subtypes (P=0.002). Cox analysis showed that the subtype was an independent prognostic indicator (P=0.001). Conclusion:In node-negative invasive breast cancer, no significant differ-ences in age distribution, tumor size, and TNM stage was observed among different subtypes. The basal-like subtype has the worst prog-nosis. Therefore, subtype is an important independent prognostic indicator.