中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
12期
776-780
,共5页
霍莉莉%李慧%魏枫%任秀宝
霍莉莉%李慧%魏楓%任秀寶
곽리리%리혜%위풍%임수보
乳腺肿瘤%P53%上皮-间质转化%预后%免疫组织化学
乳腺腫瘤%P53%上皮-間質轉化%預後%免疫組織化學
유선종류%P53%상피-간질전화%예후%면역조직화학
breast neoplasms%P53%epithelial-mesenchymal transition%prognosis%immunohistochemistry
目的：探讨乳腺癌组织中P53的表达和上皮-间质转化（EMT）的相互关系及其临床意义。方法：免疫组织化学法检测63例乳腺癌组织中P53、Twist、Snail、E-Cadherin、N-Cadherin、Vimentin和Fibronectin的表达情况，分析乳腺癌突变型P53蛋白表达与临床病理特征，患者预后和EMT发生之间的关系。结果：P53、Twist和Snail的阳性率以及EMT的发生率分别为44.4%（28/63）、54.0%（34/63）、68.3%（43/63）和41.3%（26/63）。乳腺癌P53表达与组织学分级相关（P<0.05），与其他临床病理特征无关（P>0.05）。P53与Twist、Snail的表达存在相关性，而Twist、Snail和EMT发生相关（P<0.05）。多因素分析显示，淋巴结转移、P53和EMT是乳腺癌患者预后的独立影响因素。结论：P53的表达与乳腺癌组织学分级和EMT的发生相关，是患者预后的独立影响因素，可作为乳腺癌治疗的重要靶点。
目的：探討乳腺癌組織中P53的錶達和上皮-間質轉化（EMT）的相互關繫及其臨床意義。方法：免疫組織化學法檢測63例乳腺癌組織中P53、Twist、Snail、E-Cadherin、N-Cadherin、Vimentin和Fibronectin的錶達情況，分析乳腺癌突變型P53蛋白錶達與臨床病理特徵，患者預後和EMT髮生之間的關繫。結果：P53、Twist和Snail的暘性率以及EMT的髮生率分彆為44.4%（28/63）、54.0%（34/63）、68.3%（43/63）和41.3%（26/63）。乳腺癌P53錶達與組織學分級相關（P<0.05），與其他臨床病理特徵無關（P>0.05）。P53與Twist、Snail的錶達存在相關性，而Twist、Snail和EMT髮生相關（P<0.05）。多因素分析顯示，淋巴結轉移、P53和EMT是乳腺癌患者預後的獨立影響因素。結論：P53的錶達與乳腺癌組織學分級和EMT的髮生相關，是患者預後的獨立影響因素，可作為乳腺癌治療的重要靶點。
목적：탐토유선암조직중P53적표체화상피-간질전화（EMT）적상호관계급기림상의의。방법：면역조직화학법검측63례유선암조직중P53、Twist、Snail、E-Cadherin、N-Cadherin、Vimentin화Fibronectin적표체정황，분석유선암돌변형P53단백표체여림상병리특정，환자예후화EMT발생지간적관계。결과：P53、Twist화Snail적양성솔이급EMT적발생솔분별위44.4%（28/63）、54.0%（34/63）、68.3%（43/63）화41.3%（26/63）。유선암P53표체여조직학분급상관（P<0.05），여기타림상병리특정무관（P>0.05）。P53여Twist、Snail적표체존재상관성，이Twist、Snail화EMT발생상관（P<0.05）。다인소분석현시，림파결전이、P53화EMT시유선암환자예후적독립영향인소。결론：P53적표체여유선암조직학분급화EMT적발생상관，시환자예후적독립영향인소，가작위유선암치료적중요파점。
Objective:This study aims to investigate the correlation and significance between the expression of P53 and epitheli-al-mesenchymal transition (EMT) in breast cancer. Methods:The expression patterns of P53, Twist, Snail, E-cadherin, N-cadherin, Vi-mentin, and Fibronectin protein were detected via immunohistochemistry in 63 cases with breast carcinoma. The correlation of P53 pro-tein with clinicopathologic features and survival of breast carcinoma, as well as the relationship between the expression of P53 and EMT, was analyzed. Results:The expression rates of P53, Twist, Snail, and EMT are 44.4%(28/63), 54.0%(34/63), 68.3%(43/63), and 41.3%(26/63), respectively. The P53 protein expression is correlated with tumor grade (P<0.05) but not with other clinicopatholog-ic features (P>0.05). The expression of P53 is also correlated with the expression of Twist and Snail, which are associated with EMT (P<0.05). Multivariate survival analysis reveals that lymph node metastasis, P53, and EMT are independent prognostic factors. Conclu-sion:The expression of P53 is correlated with tumor grade and EMT in breast cancer, which can be used as an independent prognostic factor. Therefore, P53 may be an effective target for breast cancer therapy.
