CAJ | 학술논문

目的：观察COPD患者痰炎性细胞分类计数、痰上清液和血清IL-6、IL-8及LTB4含量，探讨其相关性，并与健康组对比含量的差异。方法：纳入稳定期中、重度COPD患者50例做为COPD组，30例健康自愿者作为健康对照组，分别检测痰炎性细胞数和痰上清液、血清IL-6、IL-8及LTB4含量。结果：COPD组血清及痰上清液中IL-6、IL-8、LTB4含量水平明显高于健康对照组(P＜0.01)。COPD 组血清和痰上清液 IL-6含量显著相关(r=0.864，P＜0.01)；IL-8含量显著相关(r=0.938，P＜0.01)；LTB4含量有相关性(r=0.366，P＜0.05)。COPD组痰中性粒细胞计数与痰上清液IL-6含量呈显著相关(r=0.809，P＜0.01)；痰中性粒细胞计数与痰上清液IL-8含量呈显著相关(r=0.817，P＜0.01)；痰中性粒细胞计数与痰上清液LTB4含量有相关性(r=0.309，P＜0.05)。结论：COPD 组痰上清液及血清 IL-6、IL-8、LTB4含量、痰中性粒细胞计数均显著相关，且血清和痰上清液IL-8含量相关性最强，具有临床指导意义。
목적：관찰COPD환자담염성세포분류계수、담상청액화혈청IL-6、IL-8급LTB4함량，탐토기상관성，병여건강조대비함량적차이。방법：납입은정기중、중도COPD환자50례주위COPD조，30례건강자원자작위건강대조조，분별검측담염성세포수화담상청액、혈청IL-6、IL-8급LTB4함량。결과：COPD조혈청급담상청액중IL-6、IL-8、LTB4함량수평명현고우건강대조조(P＜0.01)。COPD 조혈청화담상청액 IL-6함량현저상관(r=0.864，P＜0.01)；IL-8함량현저상관(r=0.938，P＜0.01)；LTB4함량유상관성(r=0.366，P＜0.05)。COPD조담중성립세포계수여담상청액IL-6함량정현저상관(r=0.809，P＜0.01)；담중성립세포계수여담상청액IL-8함량정현저상관(r=0.817，P＜0.01)；담중성립세포계수여담상청액LTB4함량유상관성(r=0.309，P＜0.05)。결론：COPD 조담상청액급혈청 IL-6、IL-8、LTB4함량、담중성립세포계수균현저상관，차혈청화담상청액IL-8함량상관성최강，구유림상지도의의。
Objective:To observe the sputum inflammatory cells and supernatant and serum IL-6,IL-8 and LTB4 levels in COPD patients,discuss their correlation,and the difference compared with that of the healthy group.Methods:The COPD group consisting of 50 patients of moderate and severea,while the control group consisting of 30 healthy persons as volunteers.The number of inflammatory cells and the content of IL-6,IL-8 and LB4 in serum and sputum supernatants were detected respectively.Results:The serum and sputum supernatant IL-6,IL-8,LTB4 levels of COPD group were significantly higher than those of the healthy control group(P<0.01).The serum IL-6 and the sputum supernatants IL-6 were significantly correlated(r=0.864,P<0.01)in COPD group;IL-8 were significantly correlated(r=0.938,P<0.01);LTB4 were correlated(r=0.366,P<0.05).In the COPD group,the sputum neutrophils cells and supernatant IL-6 have a significant correlation(r=0.809,P<0.01),and does IL-8 in sputum(r=0.817, P<0.01).The cotent of LTB4 in the sputum and supernatant has correlation(r=0.309,P<0.05).Conclusion:In the COPD group,the serum and sputum supernatant IL-6,IL-8 and LTB4 and sputum neutrophils cells have significant correlation.IL-8 of the serum and sputum supernatant particularly has the strongest correlation which possesses a clinical significance.