CAJ | 학술논문

目的：前瞻性研究血液透析、血液透析+血液灌流、血液透析+血液透析滤过3种不同血液净化方式对维持性血液透析患者血清PTH、钙、磷的临床疗效的影响。方法：46例维持性血液透析患者随机分为血液透析组15例，血液灌流组15例和血液透析滤过组16例。观察3组试验前(0个月)、治疗6个月后血清钙、磷、PTH 水平变化。结果：血液透析组试验前(0个月)与治疗6个月后钙、磷、PTH水平无明显变化(P＞0.05)；血液透析滤过组、血液灌流组试验前(0个月)与治疗6个月后钙、磷、PTH测定水平比较，磷及PTH水平下降，钙水平升高(P＜0.05)。结论：血液透析滤过和血液灌流两种血液净化方式比血液透析能较好改善维持性血液透析患者矿物质及钙磷代谢紊乱，提高患者生活质量。
목적：전첨성연구혈액투석、혈액투석+혈액관류、혈액투석+혈액투석려과3충불동혈액정화방식대유지성혈액투석환자혈청PTH、개、린적림상료효적영향。방법：46례유지성혈액투석환자수궤분위혈액투석조15례，혈액관류조15례화혈액투석려과조16례。관찰3조시험전(0개월)、치료6개월후혈청개、린、PTH 수평변화。결과：혈액투석조시험전(0개월)여치료6개월후개、린、PTH수평무명현변화(P＞0.05)；혈액투석려과조、혈액관류조시험전(0개월)여치료6개월후개、린、PTH측정수평비교，린급PTH수평하강，개수평승고(P＜0.05)。결론：혈액투석려과화혈액관류량충혈액정화방식비혈액투석능교호개선유지성혈액투석환자광물질급개린대사문란，제고환자생활질량。
Objective:To prospective study of hemodialysis,hemoperfusion and hemodialysis,hemodialysis and hemodiafiltration about 3 different ways of blood purification on clinical curative effect of maintenance hemodialysis patients with serum PTH,calci-um,phosphorus.Methods:We selected 46 cases of maintenance hemodialysis patients.These patients were randomly divided into hemodialysis group with 15 cases,the blood perfusion group with 15 cases,and hemodiafiltration group with 16 cases.Before the experiment(0 months),6 months after treatment the changes of serum calcium,phosphorus,PTH levels were compared.The changes of serum calcium,phosphorus,PTH levels before the experiment(0 months)and 6 months after treatment were compared.Results:In hemodialysis group,there were no significant changes of calcium,phosphorus,PTH levels before the experiment(0 months)and 6 months after treatment(P>0.05);In Hemodiafiltration group and hemoperfusion group,calcium,phosphorus,PTH levels before the test(0 months)were compared with 6 months after treatment,phosphorus and PTH levels were reduced,calcium levels were elevat-ed(P<0.05).Conclusion:Compared with hemodialysis,hemoperfusion and hemodiafiltration can improve the disorder of mineral metabolism and calcium and phosphorus in maintenance hemodialysis patients,and improve patient quality of life.