CAJ | 학술논문

目的：分析2型糖尿病(T2DM)家系一级亲属同胞的代谢综合征(MS)各组分聚集情况及临床特征。方法：以41个T2DM家系中同胞一级亲属为研究组(n=98)，以同胞配偶中无糖尿病家族史的一级亲属同胞为对照组(n=85)。测定身高、腰围、体重、血压、空腹血糖、餐后2小时血糖、甘油三酯、高密度脂蛋白、胆固醇，非糖尿病者行口服葡萄糖耐量试验。其中研究组根据CDS在2004年的建议标准分为：无代谢异常组、伴1项代谢异常组、伴2项代谢异常组、伴MS组、伴1项以上代谢异常组、伴2项以上代谢异常组。对研究组的组分聚集情况及临床特征进行分析，并与对照组比较。结果：T2DM家系一级亲属同胞81.63%伴1项以上MS组分的异常，50%伴2项以上MS组分的异常，32.65%伴MS，显著高于对照组(对应的异常率分别为38.82%、29.41%、12.94%)(P＜0.01)。在糖代谢异常发生前已可出现1项或多项MS组分异常。随MS组分异常聚集的增多，其血糖、腰围、SBP、DBP、TG升高越显著，HDL-C降低越明显(P＜0.05)。结论：T2DM家系一级亲属同胞比普通人群更容易发生MS组分中1项或多项异常，对这一人群应加强健康教育、密切监测MS组分及相关代谢指标。
목적：분석2형당뇨병(T2DM)가계일급친속동포적대사종합정(MS)각조분취집정황급림상특정。방법：이41개T2DM가계중동포일급친속위연구조(n=98)，이동포배우중무당뇨병가족사적일급친속동포위대조조(n=85)。측정신고、요위、체중、혈압、공복혈당、찬후2소시혈당、감유삼지、고밀도지단백、담고순，비당뇨병자행구복포도당내량시험。기중연구조근거CDS재2004년적건의표준분위：무대사이상조、반1항대사이상조、반2항대사이상조、반MS조、반1항이상대사이상조、반2항이상대사이상조。대연구조적조분취집정황급림상특정진행분석，병여대조조비교。결과：T2DM가계일급친속동포81.63%반1항이상MS조분적이상，50%반2항이상MS조분적이상，32.65%반MS，현저고우대조조(대응적이상솔분별위38.82%、29.41%、12.94%)(P＜0.01)。재당대사이상발생전이가출현1항혹다항MS조분이상。수MS조분이상취집적증다，기혈당、요위、SBP、DBP、TG승고월현저，HDL-C강저월명현(P＜0.05)。결론：T2DM가계일급친속동포비보통인군경용역발생MS조분중1항혹다항이상，대저일인군응가강건강교육、밀절감측MS조분급상관대사지표。
Objective:To explore the component aggregation and clinical feature of metabolic syndrome in the first-degree relatives of type 2 diabetes pedigrees.Methods:We selected first-degree relatives of 41 type 2 diabetes pedigrees as study group(n=98),and we selected first-degree relatives without a family history of diabetes in their spouses as the control group(n=85).We measured some indexes,such as height,weight,waist circumference,blood pressure,fasting blood glucose,postprandial 2 hour blood glucose,triglyceride,high density lipoprotein,cholesterol.Non diabetic subjects underwent an oral glucose tolerance test.Study group was grouped according to the CDS standard in 2004:no abnormal metabolism group,with 1 metabolic abnormal group,with 2 abnormal metabolism,with MS group,with 1 or more abnormal metabolism group,with 2 or more abnormal metabolism group.We analyzed the component aggregation and clinical feature of the study groups,and compared with control group.Results:81.63% of the first-degree relatives of type 2 diabetes pedigrees had 1 or more MS component abnormity,50% had 2 or more MS component abnormity,32.65% had MS,these were significantly higher than that of control group(the abnormal rate corresponding to the study group was 38.82%,29.41%,12.94% respectively)(P<0.01).Even before the occurrence of abnormal glucose metabolism,it can appear 1 or more components of MS anomaly.With the abnormal aggregation of MS component increased,blood glucose,waist circumference,SBP,DBP,TG were increased more significantly,HDL-C was decreased more obviously(P<0.05).Conclusion:The first-degree relatives of type 2 diabetes pedigrees are more likely to occur in 1 or more abnormal of MS component compared with the general population,the crowd should be strengthened on the health education,and receive close monitoring of MS components and related metabolism indexes.