中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
15期
148-151
,共4页
ST段抬高急性心肌梗死%血浆NT-proBNP%静脉溶栓%心血管事件
ST段抬高急性心肌梗死%血漿NT-proBNP%靜脈溶栓%心血管事件
ST단태고급성심기경사%혈장NT-proBNP%정맥용전%심혈관사건
ST segment-elevation myocardial infaction%NT-proBNP%Intravenous thrombolysis%Cardiovascular events
目的:本研究旨在观察成功溶栓患者中是否发生早期心血管事件,比较其NT-proBNP的差异,并研究其与血清肌钙蛋白T(cTnT)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、左室射血分数(LVEF)、左室舒张末期直径(LVEDD)之间的相关性,探讨测定血浆NT-proBNP水平在评价急性心肌梗死(AMI)成功溶栓治疗的患者病情严重程度和预后的意义。方法:采用酶联免疫吸附法对61例ST段抬高型AMI患者应用瑞替普酶静脉溶栓治疗前测定NT-proBNP。随访30 d,观察30 d内是否发生心血管死亡、心力衰竭、再发心肌梗死、梗死后心绞痛等情况。结果:血浆NT-proBNP水平在早期有心血管事件组高于无心血管事件组,两组比较差异有统计学意义(P<0.05)。血浆NT-proBNP水平与cTnT、CK、CK-MB、LVEDD存在正相关(P<0.05),与LVEF存在负相关(P<0.05)。结论:测定入院时血浆NT-proBNP水平对评估AMI经过成功溶栓治疗的患者30 d内发生心血管事件有重要的临床价值。
目的:本研究旨在觀察成功溶栓患者中是否髮生早期心血管事件,比較其NT-proBNP的差異,併研究其與血清肌鈣蛋白T(cTnT)、肌痠激酶(CK)、肌痠激酶同工酶(CK-MB)、左室射血分數(LVEF)、左室舒張末期直徑(LVEDD)之間的相關性,探討測定血漿NT-proBNP水平在評價急性心肌梗死(AMI)成功溶栓治療的患者病情嚴重程度和預後的意義。方法:採用酶聯免疫吸附法對61例ST段抬高型AMI患者應用瑞替普酶靜脈溶栓治療前測定NT-proBNP。隨訪30 d,觀察30 d內是否髮生心血管死亡、心力衰竭、再髮心肌梗死、梗死後心絞痛等情況。結果:血漿NT-proBNP水平在早期有心血管事件組高于無心血管事件組,兩組比較差異有統計學意義(P<0.05)。血漿NT-proBNP水平與cTnT、CK、CK-MB、LVEDD存在正相關(P<0.05),與LVEF存在負相關(P<0.05)。結論:測定入院時血漿NT-proBNP水平對評估AMI經過成功溶栓治療的患者30 d內髮生心血管事件有重要的臨床價值。
목적:본연구지재관찰성공용전환자중시부발생조기심혈관사건,비교기NT-proBNP적차이,병연구기여혈청기개단백T(cTnT)、기산격매(CK)、기산격매동공매(CK-MB)、좌실사혈분수(LVEF)、좌실서장말기직경(LVEDD)지간적상관성,탐토측정혈장NT-proBNP수평재평개급성심기경사(AMI)성공용전치료적환자병정엄중정도화예후적의의。방법:채용매련면역흡부법대61례ST단태고형AMI환자응용서체보매정맥용전치료전측정NT-proBNP。수방30 d,관찰30 d내시부발생심혈관사망、심력쇠갈、재발심기경사、경사후심교통등정황。결과:혈장NT-proBNP수평재조기유심혈관사건조고우무심혈관사건조,량조비교차이유통계학의의(P<0.05)。혈장NT-proBNP수평여cTnT、CK、CK-MB、LVEDD존재정상관(P<0.05),여LVEF존재부상관(P<0.05)。결론:측정입원시혈장NT-proBNP수평대평고AMI경과성공용전치료적환자30 d내발생심혈관사건유중요적림상개치。
Objective:To observe whether early cardiovascular events occurred in patients with successful thrombolysis to explore the differences of NT-proBNP,and to detect its correlation with cTnT,CK,CK-MB,LVEF, LVEDD,and discuss the value of plasma NT-proBNP for severity and prognostic significance in the AMI patients with successful thrombolysis.Method:The plasma NT-proBNP collecting before thrombolytic therapy in 61patients with AMI was measured by enzyme-lined imunosorbent assay. All patients were followed up for 30 days,the occurrence of cardiovascular death,heart failure,recurrent AMI in 30 days,post-infarction angina,etc were observed. Result:The plasma NT-proBNP levels in the occurred vascular events group in the early periods were significantly higher than the non-occurred vascular events group,the difference was significant(P<0.05). The plasma NT-proBNP level with cTnT,CK, CK-MB,LVEDD existed positive correlation(P<0.05),and LVEF was negatively related(P<0.05). Conclusion:The plasma NT-proBNP after admission has significance clinical value to estimate the occurrence in the AMI patients with successful thrombolysis in 30 days.