中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
15期
78-80
,共3页
脑梗死%老年%同型半胱氨酸%颈动脉粥样硬化
腦梗死%老年%同型半胱氨痠%頸動脈粥樣硬化
뇌경사%노년%동형반광안산%경동맥죽양경화
Cerebral infarction%Old%Homocysteine%Carotid artery atherosclerosis
目的：探讨老年急性脑梗死患者血清同型半胱氨酸（Hcy）水平与颈动脉硬化（CAA）程度之间的关系。方法：对80例老年急性脑梗死患者进行空腹血浆Hcy、空腹血糖、胆固醇、甘油三酯、叶酸、维生素B12（VitB12）水平的测定，并且进行彩超检查颈动脉内膜-中层厚度（IMT）、斑块大小、狭窄程度及血流速度的检测，按照颈动脉狭窄程度及IMT值分为A、B、C、D四组；对Hcy水平与叶酸、VitB12及其他相关因素进行分析。结果：（1）随着CAA程度的加重，Hcy水平升高，A、B、C组和D组之间比较差异均有统计学意义（P<0.05）；（2）叶酸与VitB12的水平随着CAA程度的加重而降低，仅在A组和D组之间比较差异有统计学意义（P<0.05）；（3）统计学分析表明血清Hcy水平与血叶酸和VitB12水平负相关（r=-0.328、-0.442，P<0.05）。结论：高Hcy血症与颈动脉粥样硬化程度密切相关，是脑梗死发生的独立危险因素。
目的：探討老年急性腦梗死患者血清同型半胱氨痠（Hcy）水平與頸動脈硬化（CAA）程度之間的關繫。方法：對80例老年急性腦梗死患者進行空腹血漿Hcy、空腹血糖、膽固醇、甘油三酯、葉痠、維生素B12（VitB12）水平的測定，併且進行綵超檢查頸動脈內膜-中層厚度（IMT）、斑塊大小、狹窄程度及血流速度的檢測，按照頸動脈狹窄程度及IMT值分為A、B、C、D四組；對Hcy水平與葉痠、VitB12及其他相關因素進行分析。結果：（1）隨著CAA程度的加重，Hcy水平升高，A、B、C組和D組之間比較差異均有統計學意義（P<0.05）；（2）葉痠與VitB12的水平隨著CAA程度的加重而降低，僅在A組和D組之間比較差異有統計學意義（P<0.05）；（3）統計學分析錶明血清Hcy水平與血葉痠和VitB12水平負相關（r=-0.328、-0.442，P<0.05）。結論：高Hcy血癥與頸動脈粥樣硬化程度密切相關，是腦梗死髮生的獨立危險因素。
목적：탐토노년급성뇌경사환자혈청동형반광안산（Hcy）수평여경동맥경화（CAA）정도지간적관계。방법：대80례노년급성뇌경사환자진행공복혈장Hcy、공복혈당、담고순、감유삼지、협산、유생소B12（VitB12）수평적측정，병차진행채초검사경동맥내막-중층후도（IMT）、반괴대소、협착정도급혈류속도적검측，안조경동맥협착정도급IMT치분위A、B、C、D사조；대Hcy수평여협산、VitB12급기타상관인소진행분석。결과：（1）수착CAA정도적가중，Hcy수평승고，A、B、C조화D조지간비교차이균유통계학의의（P<0.05）；（2）협산여VitB12적수평수착CAA정도적가중이강저，부재A조화D조지간비교차이유통계학의의（P<0.05）；（3）통계학분석표명혈청Hcy수평여혈협산화VitB12수평부상관（r=-0.328、-0.442，P<0.05）。결론：고Hcy혈증여경동맥죽양경화정도밀절상관，시뇌경사발생적독립위험인소。
Objective:To analyze the relationship between the homocysteine(Hcy)and carotid artery atherosclerosis(CAA)degree on the old acute cerebral infarction.Method:80 patients with cerebral infarction were selected,plasma Hcy,fasting blood-glucose,cholesterol,triglyceride,folate and VitB12 of all subjects were measured;the intima-media thickness(IMT)of artery,patch size,degree of stenosis and blood flow velocity were detected. The patients were divided into A,B,C,D four groups according to the degree of carotid stenosis and IMT values. The Hcy levels and folic acid,VitB12 and other related factors were analyzed. Result:(1)The level of Hcy increased with aggravation of CAA,there were significant differences among A,B,C group and D group(P<0.05);(2)the level of VitB12 and folate decreased while Hcy level increased,and only the difference between A and D group was obviously (P<0.05);(3)levels of plasma Hcy were negatively correlated with VitBl2 and folic acid levels(r=-0.328,-0.442, P<0.05).Conclusion:Hyperhomocysteinemia is an important risk factor for cerebral infarction,plasma homocysteine is graded associated with carotid atherosclerosis.
