CAJ | 학술논문

目的：探讨急腹症患者早期预防性应用奥美拉唑对术后应激性溃疡(SU)的预防效果。方法：2年间收治急腹症行腹部手术患者320例，随机分为治疗组和对照组。治疗组术后常规予以奥美拉唑注射液40mg/次，2次/日，静滴；对照组手术后予以西咪替丁注射液0.4g/次，2次/日，静滴。观察并记录手术后7天急性SU的发生率。结果：对照组SU的发生率高于治疗组，差异具有统计学意义(χ2=6.81，P＜0.01)。治疗组与对照组药物不良反应差异无统计学意义(P＞0.05)。结论：急腹症患者术后尽早应用奥美拉唑可以有效预防SU的发生，且不良反应少，较为安全、经济、可靠。
목적：탐토급복증환자조기예방성응용오미랍서대술후응격성궤양(SU)적예방효과。방법：2년간수치급복증행복부수술환자320례，수궤분위치료조화대조조。치료조술후상규여이오미랍서주사액40mg/차，2차/일，정적；대조조수술후여이서미체정주사액0.4g/차，2차/일，정적。관찰병기록수술후7천급성SU적발생솔。결과：대조조SU적발생솔고우치료조，차이구유통계학의의(χ2=6.81，P＜0.01)。치료조여대조조약물불량반응차이무통계학의의(P＞0.05)。결론：급복증환자술후진조응용오미랍서가이유효예방SU적발생，차불량반응소，교위안전、경제、가고。
Objective:To investigate the effect of early prophylactic omeprazole in prevention of postoperative stress ulcer. Methods:320 patients with acute abdomen underwent abdominal operation during 2 years were selected,and they were randomly divided into the treatment group and the control group.The treatment group were given conventional omeprazole injection 40mg every time after operation,2/day,intravenous drip.The control group were given cimetidine injection 0.4g every time after operation2/day,intravenous drip.Observed and recorded the incidence of acute stress ulcer for 7 days after operation.Results:The incidence of acute stress ulcer in the control group was higher than in the treatment group,and the difference was statistically significant( χ 2=6.81, P<0.01).The incidence of aderse eents between the treatment group and the control group had no significant difference(P>0.05).Conclusion:The application of omeprazole early after acute abdomen operation can prevent the stress ulcer effectively,and it is less adverse reaction, safety and reliable.