当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
17期
5-7
,共3页
非小细胞肺癌%癌性乏力%气虚型%参芪扶正注射液
非小細胞肺癌%癌性乏力%氣虛型%參芪扶正註射液
비소세포폐암%암성핍력%기허형%삼기부정주사액
Non-small cell lung%Cancer-Related fatigue%Syndrome of deficiency of QI%Shenqifuzheng injection
目的：探讨参芪扶正注射液对于非小细胞肺癌患者术后辅助化疗后癌症相关性乏力（cancer-related fatigue，CFR)的治疗作用。方法选取2012年6月～2013年6月湖北省中医院肿瘤科收治的术后病理分期为Ⅱ～ⅢA期的非小细胞肺癌患者，给予4周期含铂的2药联合辅助化疗。对于化疗后无疾病进展，但合并有乏力症状且中医辨证属气虚证的84例患者随机分为2组（n=42）。治疗组在一般性干预处理的基础上加用静脉滴注参芪扶正注射液(治疗组)，对照组仅予以一般性干预处理(对照组)。依据简明乏力评估量表(brief inventory，BFI)，于治疗前、治疗第1周、第2周、第3周做乏力问卷评分，比较2组患者乏力程度的变化情况及不良反应的发生情况。结果治疗第2、3周时，治疗组较对照组CRF明显改善，差异有统计学意义（P＜0.05）；2组不良反应发生情况比较，差异无统计学意义。结论参芪扶正注射液可以改善Ⅱ～ⅢA期非小细胞肺癌患者术后辅助化疗后气虚型CRF，并且无严重不良反应。
目的：探討參芪扶正註射液對于非小細胞肺癌患者術後輔助化療後癌癥相關性乏力（cancer-related fatigue，CFR)的治療作用。方法選取2012年6月～2013年6月湖北省中醫院腫瘤科收治的術後病理分期為Ⅱ～ⅢA期的非小細胞肺癌患者，給予4週期含鉑的2藥聯閤輔助化療。對于化療後無疾病進展，但閤併有乏力癥狀且中醫辨證屬氣虛證的84例患者隨機分為2組（n=42）。治療組在一般性榦預處理的基礎上加用靜脈滴註參芪扶正註射液(治療組)，對照組僅予以一般性榦預處理(對照組)。依據簡明乏力評估量錶(brief inventory，BFI)，于治療前、治療第1週、第2週、第3週做乏力問捲評分，比較2組患者乏力程度的變化情況及不良反應的髮生情況。結果治療第2、3週時，治療組較對照組CRF明顯改善，差異有統計學意義（P＜0.05）；2組不良反應髮生情況比較，差異無統計學意義。結論參芪扶正註射液可以改善Ⅱ～ⅢA期非小細胞肺癌患者術後輔助化療後氣虛型CRF，併且無嚴重不良反應。
목적：탐토삼기부정주사액대우비소세포폐암환자술후보조화료후암증상관성핍력（cancer-related fatigue，CFR)적치료작용。방법선취2012년6월～2013년6월호북성중의원종류과수치적술후병리분기위Ⅱ～ⅢA기적비소세포폐암환자，급여4주기함박적2약연합보조화료。대우화료후무질병진전，단합병유핍력증상차중의변증속기허증적84례환자수궤분위2조（n=42）。치료조재일반성간예처리적기출상가용정맥적주삼기부정주사액(치료조)，대조조부여이일반성간예처리(대조조)。의거간명핍력평고량표(brief inventory，BFI)，우치료전、치료제1주、제2주、제3주주핍력문권평분，비교2조환자핍력정도적변화정황급불량반응적발생정황。결과치료제2、3주시，치료조교대조조CRF명현개선，차이유통계학의의（P＜0.05）；2조불량반응발생정황비교，차이무통계학의의。결론삼기부정주사액가이개선Ⅱ～ⅢA기비소세포폐암환자술후보조화료후기허형CRF，병차무엄중불량반응。
Objective To investigate the effectiveness of Shenqifuzheng injection for cancer-relatedfatigue in non-small cell lung cancer patients ofⅡ-ⅢA stage after Adjuvant Chemotherapy.Methods Eighty -four non- small cell lung cancer patients ofⅡ-ⅢA stage after surgical operation and Adjuvant Chemotherapy with fatigue symptoms from June 2012 to June 2013 in our hospital were divided into two groups by random assignment.One group of 42 patients received general intervention treatment and intravenous infusion of Shenqifuzheng injection (experimental group),the other group of 42 patients only received general intervention treatment (control group).All the eighty-four patients were diagnosed with syndrome of deficiency of QI.Brief fatigue inventory (BFI) questionnaires data were collected at baseline,thefirst week,the second week and the third week after treatment.The changes of fatigue severity and the adverse reactions in the two groups were compared.Results At the second week and the third week,the improvement in fatigue severity was significantly different between two groups. However,the adverse reactions were not significantly different between two groups.Condusion Shenqifuzheng injection can improve the cancer-related fatigue of non - small cell lung cancer patients ofⅡ-ⅢA stage after Adjuvant Chemotherapy which were diagnosed with syndrome of deficiency of QI.
