CAJ | 학술논문

成熟的弹性纤维主要由弹性蛋白、原纤维蛋白微纤维及与弹性纤维有关的蛋白组成.内源性老化的皮肤弹性和柔韧度降低,弹性纤维网断裂和衰退.光老化皮肤不仅是富含原纤维蛋白的微纤维在表皮真皮交界处丢失,弹性蛋白变性,更重要的是在真皮深层混乱的弹性纤维蛋白物质的沉积,弹性蛋白的功能也受到影响.弹性纤维的修复可归纳为促进组成蛋白表达、改善组装条件、减少破坏因素3方面.
성숙적탄성섬유주요유탄성단백、원섬유단백미섬유급여탄성섬유유관적단백조성.내원성노화적피부탄성화유인도강저,탄성섬유망단렬화쇠퇴.광노화피부불부시부함원섬유단백적미섬유재표피진피교계처주실,탄성단백변성,경중요적시재진피심층혼란적탄성섬유단백물질적침적,탄성단백적공능야수도영향.탄성섬유적수복가귀납위촉진조성단백표체、개선조장조건、감소파배인소3방면.
Mature elastic fibers are mainly composed of elastin,fibrillin microfibrils and some proteins.Endogenously aged skin is manifested as a decrease in skin elasticity and flexibility as well as rupture and degeneration of elastic fibers,while photoaged skin not only involves disappearance of fibrillin-rich microfibrils in the epidermal-dermal junction,denaturation of elastic protein,but also deposition of disarranged elastic fibrous protein materials in the deep dermis with impaired function of elastic protein.The repair of elastic fibers may be realized by promoting component protein expression,improving assembly condition and reducing damage-related factors.