国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
20期
60-63
,共4页
唐言英%李怡新%刘金秀%钟永锋
唐言英%李怡新%劉金秀%鐘永鋒
당언영%리이신%류금수%종영봉
十二指肠球部溃疡%幽门螺杆菌感染%序贯疗法%传统三联疗法%Hp根除率
十二指腸毬部潰瘍%幽門螺桿菌感染%序貫療法%傳統三聯療法%Hp根除率
십이지장구부궤양%유문라간균감염%서관요법%전통삼련요법%Hp근제솔
Duodenobulbar ulcer%Helicobacter pylori%Sequential therapy%Traditional triple therapy: Eradication rate of Helicobacter pylori
目的 观察序贯疗法治疗十二指肠球部溃疡(DU)并幽门螺杆菌(Hp)感染的疗效.方法 选择前3日内经内镜检查证实为活动性DU,溃疡长径超过3mm; 14碳-尿素呼气试验(14C-UBT)确诊Hp(+)的60例患者,按随机分为两组,传统三联疗法组:奥美拉唑20mg,1日2次,疗程4周,前10天加服克拉霉素0.5g,1日 2次,阿莫西林1g,1日2次;序贯疗法组:奥美拉唑20mg,1日2次,疗程4周,前5天加用阿莫西林1g,1日2次,第6～10天加用克拉霉素0.5g,1日2次,甲硝唑0.4g,1日2次.结果 传统i联疗法组溃疡愈合率80%,Hp根除率77%;序贯疗法组溃疡愈合率90%,Hp根除率97%.结论 序贯疗法具有溃疡愈合率及Hp根除率高的优点.可作为DU并Hp感染的一线治疗方案.
目的 觀察序貫療法治療十二指腸毬部潰瘍(DU)併幽門螺桿菌(Hp)感染的療效.方法 選擇前3日內經內鏡檢查證實為活動性DU,潰瘍長徑超過3mm; 14碳-尿素呼氣試驗(14C-UBT)確診Hp(+)的60例患者,按隨機分為兩組,傳統三聯療法組:奧美拉唑20mg,1日2次,療程4週,前10天加服剋拉黴素0.5g,1日 2次,阿莫西林1g,1日2次;序貫療法組:奧美拉唑20mg,1日2次,療程4週,前5天加用阿莫西林1g,1日2次,第6～10天加用剋拉黴素0.5g,1日2次,甲硝唑0.4g,1日2次.結果 傳統i聯療法組潰瘍愈閤率80%,Hp根除率77%;序貫療法組潰瘍愈閤率90%,Hp根除率97%.結論 序貫療法具有潰瘍愈閤率及Hp根除率高的優點.可作為DU併Hp感染的一線治療方案.
목적 관찰서관요법치료십이지장구부궤양(DU)병유문라간균(Hp)감염적료효.방법 선택전3일내경내경검사증실위활동성DU,궤양장경초과3mm; 14탄-뇨소호기시험(14C-UBT)학진Hp(+)적60례환자,안수궤분위량조,전통삼련요법조:오미랍서20mg,1일2차,료정4주,전10천가복극랍매소0.5g,1일 2차,아막서림1g,1일2차;서관요법조:오미랍서20mg,1일2차,료정4주,전5천가용아막서림1g,1일2차,제6～10천가용극랍매소0.5g,1일2차,갑초서0.4g,1일2차.결과 전통i련요법조궤양유합솔80%,Hp근제솔77%;서관요법조궤양유합솔90%,Hp근제솔97%.결론 서관요법구유궤양유합솔급Hp근제솔고적우점.가작위DU병Hp감염적일선치료방안.
Objective To observe the curative effect of the sequential therapy in the treatment for the duodenobnlbar ulcer with Helicobacter pylori(Hp) infection.Methods 60 activity duodenobulbar ulcer (deer size ≥ 0.3cm in diameter) proved by endosoopy patients with Hp positive who were detected by 14C urea breath test were randomly divided into two groups. Both of these groups were treated with 4-week therapy: Omeprazole(20 mg twice daily) together with either Amoxicillin (0.5g twice daily) and Clarithromyein (1 g twice daily) for the first 10 days (the traditionahriple group) or Amoxicillin(1g twice daily) for the first 5 days, then Clarithromycin (0.5g twice daily) and Metronidazole (0.4g twice daily) at the second five days (the sequential group).Results The ulcer healing rates in the traditional triplegroup and the sequential group were 80% and 90%.The eradication rate of the traditional triple group was77% and that of sequential therapy was 97%.Conclusions Sequential therapy is more effective in ulcer healing and Hp eradication.
