上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
19期
46-49
,共4页
急性肾功能衰竭%白细胞计数%血小板参数
急性腎功能衰竭%白細胞計數%血小闆參數
급성신공능쇠갈%백세포계수%혈소판삼수
acute renal failure%white blood cell count%platelet parameters
目的：探讨急性肾功能衰竭（acute renal failure, ARF）患者外周血白细胞（white blood cell, WBC）计数和血小板（platelet, PLT）参数值的变化及临床意义。方法：选取67例ARF患者（观察组）和65例慢性肾炎患者（对照组）作为研究对象，采用全自动血细胞分析方法检测患者的外周血WBC计数和PLT参数值，包括PLT计数、平均PLT体积（mean platelet volume, MPV）、PLT体积宽度分布（platelet volume distribution width, PDW）、PLT压积（thrombocytocrit, PCT）和红细胞分布宽度（red cell distribution width, RDW），同时按照《有关急性肾损伤的肾病改善综合结果》（Kidney Disease Improvement Global Outcomes for Acute Kidney Injury）中的疾病分期标准评估患者的病情严重程度。结果：观察组患者的外周血WBC计数显著高于对照组患者（P＜0.05），PLT计数、MPV、PDW和PCT均显著低于对照组患者（P均＜0.05），但两组患者RDW的差异无统计学意义；ARFⅠ期患者的外周血WBC计数、PLT计数、MPV、PDW、PCT均显著好于Ⅱ、Ⅲ期患者（P均＜0.05），Ⅱ期患者的外周血WBC计数、PLT计数、MPV、PDW、PCT均显著好于Ⅲ期患者（P均＜0.05）；ARF患者的死亡率为14.93%、感染率为77.61%、出血率为26.87%，其中无并发症患者的外周血WBC计数、PLT计数、MPV、PDW和PCT均显著好于有并发症的患者（P均＜0.05）。结论：检测外周血WBC计数和PLT参数值的变化对ARF患者的病情严重程度和预后评估具有重要的临床意义。
目的：探討急性腎功能衰竭（acute renal failure, ARF）患者外週血白細胞（white blood cell, WBC）計數和血小闆（platelet, PLT）參數值的變化及臨床意義。方法：選取67例ARF患者（觀察組）和65例慢性腎炎患者（對照組）作為研究對象，採用全自動血細胞分析方法檢測患者的外週血WBC計數和PLT參數值，包括PLT計數、平均PLT體積（mean platelet volume, MPV）、PLT體積寬度分佈（platelet volume distribution width, PDW）、PLT壓積（thrombocytocrit, PCT）和紅細胞分佈寬度（red cell distribution width, RDW），同時按照《有關急性腎損傷的腎病改善綜閤結果》（Kidney Disease Improvement Global Outcomes for Acute Kidney Injury）中的疾病分期標準評估患者的病情嚴重程度。結果：觀察組患者的外週血WBC計數顯著高于對照組患者（P＜0.05），PLT計數、MPV、PDW和PCT均顯著低于對照組患者（P均＜0.05），但兩組患者RDW的差異無統計學意義；ARFⅠ期患者的外週血WBC計數、PLT計數、MPV、PDW、PCT均顯著好于Ⅱ、Ⅲ期患者（P均＜0.05），Ⅱ期患者的外週血WBC計數、PLT計數、MPV、PDW、PCT均顯著好于Ⅲ期患者（P均＜0.05）；ARF患者的死亡率為14.93%、感染率為77.61%、齣血率為26.87%，其中無併髮癥患者的外週血WBC計數、PLT計數、MPV、PDW和PCT均顯著好于有併髮癥的患者（P均＜0.05）。結論：檢測外週血WBC計數和PLT參數值的變化對ARF患者的病情嚴重程度和預後評估具有重要的臨床意義。
목적：탐토급성신공능쇠갈（acute renal failure, ARF）환자외주혈백세포（white blood cell, WBC）계수화혈소판（platelet, PLT）삼수치적변화급림상의의。방법：선취67례ARF환자（관찰조）화65례만성신염환자（대조조）작위연구대상，채용전자동혈세포분석방법검측환자적외주혈WBC계수화PLT삼수치，포괄PLT계수、평균PLT체적（mean platelet volume, MPV）、PLT체적관도분포（platelet volume distribution width, PDW）、PLT압적（thrombocytocrit, PCT）화홍세포분포관도（red cell distribution width, RDW），동시안조《유관급성신손상적신병개선종합결과》（Kidney Disease Improvement Global Outcomes for Acute Kidney Injury）중적질병분기표준평고환자적병정엄중정도。결과：관찰조환자적외주혈WBC계수현저고우대조조환자（P＜0.05），PLT계수、MPV、PDW화PCT균현저저우대조조환자（P균＜0.05），단량조환자RDW적차이무통계학의의；ARFⅠ기환자적외주혈WBC계수、PLT계수、MPV、PDW、PCT균현저호우Ⅱ、Ⅲ기환자（P균＜0.05），Ⅱ기환자적외주혈WBC계수、PLT계수、MPV、PDW、PCT균현저호우Ⅲ기환자（P균＜0.05）；ARF환자적사망솔위14.93%、감염솔위77.61%、출혈솔위26.87%，기중무병발증환자적외주혈WBC계수、PLT계수、MPV、PDW화PCT균현저호우유병발증적환자（P균＜0.05）。결론：검측외주혈WBC계수화PLT삼수치적변화대ARF환자적병정엄중정도화예후평고구유중요적림상의의。
Objective:To study the changes of peripheral white blood cell (WBC) count and platelet (PLT) parameters in patients with acute renal failure (ARF) and their clinical signiifcance. Methods:Sixty-seven patients with ARF were selected as an observation group and 65 cases of normal subjects as a control group, and peripheral WBC count and PLT parameters such as mean PLT volume (MPV), PLT volume distribution width (PDW), thrombocytocrit (PCT), and red cell distribution width (RDW) were detected by an automatic blood cell analysis method and ARF severity of patients were assessed by disease staging criteria in Kidney Disease Improvement Global Outcomes for Acute Kidney Injury. Results:Peripheral WBC count was signiifcantly higher while PLT, MPV, PDW and PCT were signiifcantly lower in the observation group than in the control group (P<0.05), however, the difference of RDW between two groups was not signiifcant. Peripheral WBC count, PLT, MPV, PDW, and PCT were obviously better in patients with stage I than with stage II, III and all the indexes were better in patients with stage II than with the stage III (P<0.05). Mortality accounted for 14.93%, infection rate 77.61%and bleeding rate 26.87%in the patients with ARF. Peripheral WBC count, PLT, MPV, PDW, and PCT were better in patients without complications than with complications (P<0.05). Conclusion: Detection of peripheral WBC count and PLT parameters play an important role in evaluation of the severity and prognosis of ARF.
