CAJ | 학술논문

心境稳定剂在儿童和青少年心理和行为障碍治疗中的应用广泛，适用于治疗双相情感障碍、破坏性行为障碍和注意力缺陷-多动障碍等行为障碍患者出现的冲动和攻击行为以及情绪不稳定和易激惹等表现，同时对发育迟缓儿童如精神发育迟滞和孤独症等患者出现的伤害他人或自伤行为治疗也有效果。在经典的心境稳定剂中，锂盐是唯一获准可一线用于儿童和青少年双相情感障碍患者躁狂发作和维持治疗的药物，而丙戊酸盐、卡马西平、奥卡西平和拉莫三嗪在治疗儿童攻击性或破坏性行为中也有一定的临床应用。选用心境稳定剂治疗儿童精神障碍时应考虑药物的疗效证据、安全性和不良反应以及患者的靶症状、疾病史、用药史和家族史等，以确保儿童用药安全、有效。
심경은정제재인동화청소년심리화행위장애치료중적응용엄범，괄용우치료쌍상정감장애、파배성행위장애화주의력결함-다동장애등행위장애환자출현적충동화공격행위이급정서불은정화역격야등표현，동시대발육지완인동여정신발육지체화고독증등환자출현적상해타인혹자상행위치료야유효과。재경전적심경은정제중，리염시유일획준가일선용우인동화청소년쌍상정감장애환자조광발작화유지치료적약물，이병무산염、잡마서평、오잡서평화랍막삼진재치료인동공격성혹파배성행위중야유일정적림상응용。선용심경은정제치료인동정신장애시응고필약물적료효증거、안전성화불량반응이급환자적파증상、질병사、용약사화가족사등，이학보인동용약안전、유효。
Mood stabilizers have been widely used in psychological and behavioral disorders in children and adolescents, including bipolar disorder, disruptive behavior disorders, attention deifcit hyperactivity disorder and other behavioral disorders that appear in aggressive behavior, and emotional instability, irritability and other symptoms and they can be applied in the treatment of the delay of development such as mental retardation, and autism appeared to harm others or have the self-injurious behavior in children. Among classic mood stabilizers, lithium is the only approved ifrst-line therapy for the treatment of manic episodes and maintenance in children and adolescents with bipolar disorder, and valproate and carbamazepine, oxcarbazepine and lamotrigine can also be applied in the certain treatment of children with aggressive or disruptive behavior. The evidence of drug efifcacy, safety and adverse reactions, target symptoms, disease, medication and even family history should be considered when a mood stabilizer is going to use so as to ensure the safe and effective medication in children and adolescents.