国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2014年
2期
116-119
,共4页
沈长兵%尹先勇%杨森%张学军
瀋長兵%尹先勇%楊森%張學軍
침장병%윤선용%양삼%장학군
银屑病%白细胞介素23%Thl7细胞%通路
銀屑病%白細胞介素23%Thl7細胞%通路
은설병%백세포개소23%Thl7세포%통로
Psoriasis%Interleukin-23%Th17 cells%Pathway
近年来,研究者广泛开展银屑病IL-23/Th 17通路的遗传学研究,发现该通路多个相关基因,如IL12B、IL23R、TYK2、STAT3和TRAF3IP2等与银屑病的易感性强关联.研究者进一步探讨该通路中基因-基因交互作用对银屑病发病的影响,为银屑病的遗传学发病机制研究提供了新的内容.未来还需对该通路相关基因和基因-基因交互作用进行深入研究,最终将研究成果转化到银屑病的临床应用.
近年來,研究者廣汎開展銀屑病IL-23/Th 17通路的遺傳學研究,髮現該通路多箇相關基因,如IL12B、IL23R、TYK2、STAT3和TRAF3IP2等與銀屑病的易感性彊關聯.研究者進一步探討該通路中基因-基因交互作用對銀屑病髮病的影響,為銀屑病的遺傳學髮病機製研究提供瞭新的內容.未來還需對該通路相關基因和基因-基因交互作用進行深入研究,最終將研究成果轉化到銀屑病的臨床應用.
근년래,연구자엄범개전은설병IL-23/Th 17통로적유전학연구,발현해통로다개상관기인,여IL12B、IL23R、TYK2、STAT3화TRAF3IP2등여은설병적역감성강관련.연구자진일보탐토해통로중기인-기인교호작용대은설병발병적영향,위은설병적유전학발병궤제연구제공료신적내용.미래환수대해통로상관기인화기인-기인교호작용진행심입연구,최종장연구성과전화도은설병적림상응용.
Recently,the interleukin (IL)-23/T helper type 17 (Th17) cell pathway has been extensively studied in psoriasis,and many genes in this pathway,such as IL-12B,IL-23R,TYK2,STAT3 and TRAF3IP2,are found to be closely associated with the susceptibility to psoriasis.Moreover,researchers have been investigating the effect of gene-gene interactions in this pathway on the development of psoriasis,which may broaden the knowledge on genetic pathogenesis of psoriasis.Further studies are still needed to focus on the pathway-related genes and their interactions and to translate these achievements into clinical practice in the future.
