浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
ZHEJIANG JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
7期
583-585
,共3页
不稳定型心绞痛%前列地尔%IL-6%IL-10%TNF-琢
不穩定型心絞痛%前列地爾%IL-6%IL-10%TNF-琢
불은정형심교통%전렬지이%IL-6%IL-10%TNF-탁
unstable angina%alprostadil%IL-6%IL-10%TNF-α
目的：观察前列地尔治疗不稳定性心绞痛临床疗效及对血白细胞素6、10（IL-6、IL-10）、肿瘤坏死因子琢（TNF-琢）水平的影响。方法不稳定心绞痛患者80例，随机分为对照组（40例）和治疗组（40例）。对照组患者给予常规对症支持治疗，观察组患者在对照组基础上加用前列地尔治疗，比较两组临床效果、心电图改善情况、血IL-6、TNF-琢、IL-10水平。结果治疗后，治疗组心绞痛、心电图显效率（42.5%、47.5%）均明显高于对照组（20.0%、25.0%），差异有统计学意义（字2=5.431，6.243，P<0.05）；两组治疗后血IL-6、TNF-琢水平较治疗前明显降低、IL-10水平明显升高（P<0.05， P<0.01），治疗组改善优于对照组（P<0.05）。结论前列地尔可有效抑制炎症反应，改善不稳定型心绞痛患者的临床症状。
目的：觀察前列地爾治療不穩定性心絞痛臨床療效及對血白細胞素6、10（IL-6、IL-10）、腫瘤壞死因子琢（TNF-琢）水平的影響。方法不穩定心絞痛患者80例，隨機分為對照組（40例）和治療組（40例）。對照組患者給予常規對癥支持治療，觀察組患者在對照組基礎上加用前列地爾治療，比較兩組臨床效果、心電圖改善情況、血IL-6、TNF-琢、IL-10水平。結果治療後，治療組心絞痛、心電圖顯效率（42.5%、47.5%）均明顯高于對照組（20.0%、25.0%），差異有統計學意義（字2=5.431，6.243，P<0.05）；兩組治療後血IL-6、TNF-琢水平較治療前明顯降低、IL-10水平明顯升高（P<0.05， P<0.01），治療組改善優于對照組（P<0.05）。結論前列地爾可有效抑製炎癥反應，改善不穩定型心絞痛患者的臨床癥狀。
목적：관찰전렬지이치료불은정성심교통림상료효급대혈백세포소6、10（IL-6、IL-10）、종류배사인자탁（TNF-탁）수평적영향。방법불은정심교통환자80례，수궤분위대조조（40례）화치료조（40례）。대조조환자급여상규대증지지치료，관찰조환자재대조조기출상가용전렬지이치료，비교량조림상효과、심전도개선정황、혈IL-6、TNF-탁、IL-10수평。결과치료후，치료조심교통、심전도현효솔（42.5%、47.5%）균명현고우대조조（20.0%、25.0%），차이유통계학의의（자2=5.431，6.243，P<0.05）；량조치료후혈IL-6、TNF-탁수평교치료전명현강저、IL-10수평명현승고（P<0.05， P<0.01），치료조개선우우대조조（P<0.05）。결론전렬지이가유효억제염증반응，개선불은정형심교통환자적림상증상。
Objective To investigate the clinical efficacy of alprostadil in the treatment of unstable angina and its effect on levels of interleukin-10(IL-10),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α). Methods Eighty patients with unstable angina admitted in Cardiovascular Department of People's Hospital of Qingtian and Central Hospital of Lishui from January,2012 to January,2013 were enrolled in this study.The patients were divided into two groups:control group(n=40)and treatment group(n=40). The patient in control group was given general symptomatic and supportive treatment and the patient in treatment group was given alprostadil plus general symp- tomatic treatment. Clinical effects,ECG improvement,and the level of IL-6,TNF-α,IL-10 were compared between two groups. Results The clinical efficacy in treatment group was higher than that in control group (42.5% vs 20%),with a statistical difference(x2=5.431,P<0.05),and the same increase in ECG efficacy was seen in treatment group(47.5% vs 25%,x2=5.431,P<0.05). After treatment, the level of IL-6 and TNF-αin both groups were signifi- cantly lower and the level of IL-10 was higher than those before treatment(P<0.05);the level of IL-6 and TNF-α in treatment group had more decrease and the level of IL-10 had more increase than those in control group after treatment(P<0.05). Conclusion Alprostadil can effectively suppress inflammation and improve clinical symptoms in patients with angina.
