CAJ | 학술논문

目的：探讨老年急性脑梗死患者血浆8-异前列腺素F2α（8-iso-PGF2α）的变化及与神经功能缺失程度的关系。方法将67例急性脑梗死患者分为中青年组30例（＜60岁）和老年组（≥60岁）37例，另择30例健康体检者（≥60岁）为老年对照组。采用ELISA法检测脑梗死患者血浆8-iso-PGF2α水平，采用美国国立卫生研究院脑卒中量表(NIHSS)评分进行神经功能缺损评估。结果老年组血浆8-iso-PGF2α水平(506.38±138.63)ng/L高于老年对照组(369.98±99.81)ng/L和中青年组(420.18±132.72)ng/L，中青年组与老年对照组差异无统计学意义（F=9.272，P＜0.05）。老年组NIHSS评分高于中青年组[（19.78±3.66）vs（17.73±2.70），t=2.539，P＜0.05]。老年组血浆8-iso-PGF2α与NIHSS评分呈正相关（r=0.504，P=0.001）。结论氧化应激在老年急性脑梗死患者的发生、发展过程中起着重要的作用，尽早合理的抗氧化治疗可以减轻临床症状，促进病情恢复。
목적：탐토노년급성뇌경사환자혈장8-이전렬선소F2α（8-iso-PGF2α）적변화급여신경공능결실정도적관계。방법장67례급성뇌경사환자분위중청년조30례（＜60세）화노년조（≥60세）37례，령택30례건강체검자（≥60세）위노년대조조。채용ELISA법검측뇌경사환자혈장8-iso-PGF2α수평，채용미국국립위생연구원뇌졸중량표(NIHSS)평분진행신경공능결손평고。결과노년조혈장8-iso-PGF2α수평(506.38±138.63)ng/L고우노년대조조(369.98±99.81)ng/L화중청년조(420.18±132.72)ng/L，중청년조여노년대조조차이무통계학의의（F=9.272，P＜0.05）。노년조NIHSS평분고우중청년조[（19.78±3.66）vs（17.73±2.70），t=2.539，P＜0.05]。노년조혈장8-iso-PGF2α여NIHSS평분정정상관（r=0.504，P=0.001）。결론양화응격재노년급성뇌경사환자적발생、발전과정중기착중요적작용，진조합리적항양화치료가이감경림상증상，촉진병정회복。
Objective To investigate the relationship between the level of 8-iso-prostaglandin (8-iso-PG)F2αand the neural functional deficit in patients with acute cerebral infarction (ACI). Methods Sixty-seven ACI patients were se-lected in Neurological Department of Ganyu People’s Hospital. According to the age, these subjects were divided into two groups:the old group (≥60 years, n=37) and middle-young group (<60 years, n=30). Thirty healthy subjects were selected as controls (≥60 years). The age, gender and anamnesis were matched in two groups of elderly people. The ELISA was used to detect the plasma levels of 8-iso-PGF2αin two groups of patients. And NIHSS score was used to evaluate the severity of clinical neurological deficit. Results The plasma levels of 8-iso-PGF2α were significantly higher in old ACI group (506.38±138.63) ng/L than those of middle-young ACI group (420.18±132.72) ng/L and old control group (369.98±99.81) ng/L. There was no significant difference in plasma level of 8-iso-PGF2αbetween middle-young ACI group and old control group (F=9.272,P<0.05). The NIHSS score was significantly higher in old group (19.78±3.66) than that of middle-young group (17.73 ± 2.70, t=2.539,P<0.05). There was a positive correlation between plasma 8-iso-PGF2α level and NIHSS score in old group (r=0.504,P=0.001). Conclusion The oxidative stress plays an important role in the occurrence and de-velopment process of ACI in elderly patients. The earlier and reasonable antioxidant therapy plays a positive role to alleviate the clinical symptoms and promote the recovery of illness.