天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
7期
674-676
,共3页
卒中%脑梗死%脑损伤%神经元特异性烯醇化酶
卒中%腦梗死%腦損傷%神經元特異性烯醇化酶
졸중%뇌경사%뇌손상%신경원특이성희순화매
stroke%brain infarction%brain injuries%neuron-specific enolase
目的:探讨缺血性卒中急性期血清神经元特异性烯醇化酶(NSE)水平与脑损伤程度的相关性。方法将急性缺血性卒中患者100例根据牛津郡社区卒中计划(OCSP)进行分型,测定血清NSE水平并使用开放源图像处理软件OsiriX计算脑梗死体积,对血清NSE水平与脑梗死体积和缺血性卒中亚型的相关性进行分析。结果按血清NSE中分位数截取点11.46μg/L将患者分为2组进行比较,NSE>11.46μg/L组患者入院美国国立卫生研究院卒中量表(NIHSS)评分较高[6.0(4.0,10.0)分vs 4.0(2.0,6.0)分]、脑梗死体积较大[4.3(1.3,15.9)cm3 vs 0.8(0.4,4.3)cm3],差异有统计学意义。完全前循环梗死(TACI)、部分前循环梗死(PACI)、后循环梗死(POCI)、腔隙性梗死(LACI)患者血清NSE水平(μg/L)分别为16.7(10.0,27.4)、11.5(10.1,13.8)、11.0(9.9,14.6)和10.3(9.5,11.1),各组间差异有统计学意义。血清NSE与脑梗死体积呈正相关(rs=0.417,P<0.01),并且两者存在线性回归关系,回归方程为=2.438+0.100 X(X:脑梗死体积;Y:血清NSE)。结论血清NSE可作为判断缺血性卒中患者脑损伤程度的一种简易血清生物学标志物。
目的:探討缺血性卒中急性期血清神經元特異性烯醇化酶(NSE)水平與腦損傷程度的相關性。方法將急性缺血性卒中患者100例根據牛津郡社區卒中計劃(OCSP)進行分型,測定血清NSE水平併使用開放源圖像處理軟件OsiriX計算腦梗死體積,對血清NSE水平與腦梗死體積和缺血性卒中亞型的相關性進行分析。結果按血清NSE中分位數截取點11.46μg/L將患者分為2組進行比較,NSE>11.46μg/L組患者入院美國國立衛生研究院卒中量錶(NIHSS)評分較高[6.0(4.0,10.0)分vs 4.0(2.0,6.0)分]、腦梗死體積較大[4.3(1.3,15.9)cm3 vs 0.8(0.4,4.3)cm3],差異有統計學意義。完全前循環梗死(TACI)、部分前循環梗死(PACI)、後循環梗死(POCI)、腔隙性梗死(LACI)患者血清NSE水平(μg/L)分彆為16.7(10.0,27.4)、11.5(10.1,13.8)、11.0(9.9,14.6)和10.3(9.5,11.1),各組間差異有統計學意義。血清NSE與腦梗死體積呈正相關(rs=0.417,P<0.01),併且兩者存在線性迴歸關繫,迴歸方程為=2.438+0.100 X(X:腦梗死體積;Y:血清NSE)。結論血清NSE可作為判斷缺血性卒中患者腦損傷程度的一種簡易血清生物學標誌物。
목적:탐토결혈성졸중급성기혈청신경원특이성희순화매(NSE)수평여뇌손상정도적상관성。방법장급성결혈성졸중환자100례근거우진군사구졸중계화(OCSP)진행분형,측정혈청NSE수평병사용개방원도상처리연건OsiriX계산뇌경사체적,대혈청NSE수평여뇌경사체적화결혈성졸중아형적상관성진행분석。결과안혈청NSE중분위수절취점11.46μg/L장환자분위2조진행비교,NSE>11.46μg/L조환자입원미국국립위생연구원졸중량표(NIHSS)평분교고[6.0(4.0,10.0)분vs 4.0(2.0,6.0)분]、뇌경사체적교대[4.3(1.3,15.9)cm3 vs 0.8(0.4,4.3)cm3],차이유통계학의의。완전전순배경사(TACI)、부분전순배경사(PACI)、후순배경사(POCI)、강극성경사(LACI)환자혈청NSE수평(μg/L)분별위16.7(10.0,27.4)、11.5(10.1,13.8)、11.0(9.9,14.6)화10.3(9.5,11.1),각조간차이유통계학의의。혈청NSE여뇌경사체적정정상관(rs=0.417,P<0.01),병차량자존재선성회귀관계,회귀방정위=2.438+0.100 X(X:뇌경사체적;Y:혈청NSE)。결론혈청NSE가작위판단결혈성졸중환자뇌손상정도적일충간역혈청생물학표지물。
Objective To investigate the relationship between serum neuron-specific enolase (NSE) level and the severity of brain injury in patients with acute ischemic stroke. Methods A total of 100 patients with acute ischemic stroke, classified as total anterior circulation infarct (TACI), partial anterior circulation infarct (PACI), posterior circalation infarct (POCI) and lacunar infarct (LACI) were included in this study. The serum levels of NSE were detected and cerebral infarc-tion volumes were measured using 32-bit OsiriX imaging software. The correlation between serum level of NSE, cerebral in-farction volume and subtypes of ischemic stroke was analyzed. Results Patients were divided into NSE≤11.46μg/L group and NSE>11.46μg/L group. The scores of NIHSS[6.0(4.0, 10.0) vs 4.0(2.0, 6.0)]were higher, the infarction volumes[4.3 (1.3, 15.9) cm3 vs 0.8(0.4,4.3) cm3]were larger in NSE>11.46μg/L group (P<0.05). The serum NSE level showed statistical-ly significant difference between TACI and other groups (P<0.01). The increased serum NSE level was correlated with in-creased infarction volume (rs=0.417,P<0.01). There was a linear regression between serum NSE level and infarction vol-ume. Its linear regression equation was =2.438+0.100 X (X:infarction volume;Y:serum NSE level). Conclusion The se-rum NSE level may be helpful for the prediction of the severity of brain injured in patients with acute ischemic stroke.