CAJ | 학술논문

目的：比较阿立哌唑与舒必利治疗精神分裂症阴性症状的疗效和安全性。方法选取120例符合中国精神疾病诊断标准（CCMD3）诊断为精神分裂症且以阴性症状为主的患者，根据随机对照的方法分为研究组（60例）和对照组（60例），研究组应用阿立哌唑治疗，对照组舒必利治疗，疗程均为3个月；用阴性症状评定量表(SANS)、用药物副反应量表(TESS)进行评定。结果两组治疗前后1个月比较有显著性差异（P＜0.05），治疗后2、3个月与治疗前比较亦有显著性差异（P＜0.05）；两组药物副反应比较，阿立哌唑组明显舒必利组少，有显著性差异（P＜0.05）。结论阿立哌唑对分裂症阴性症状有较好的治疗效果，药物副反应少，使用安全较高。
목적：비교아립고서여서필리치료정신분렬증음성증상적료효화안전성。방법선취120례부합중국정신질병진단표준（CCMD3）진단위정신분렬증차이음성증상위주적환자，근거수궤대조적방법분위연구조（60례）화대조조（60례），연구조응용아립고서치료，대조조서필리치료，료정균위3개월；용음성증상평정량표(SANS)、용약물부반응량표(TESS)진행평정。결과량조치료전후1개월비교유현저성차이（P＜0.05），치료후2、3개월여치료전비교역유현저성차이（P＜0.05）；량조약물부반응비교，아립고서조명현서필리조소，유현저성차이（P＜0.05）。결론아립고서대분렬증음성증상유교호적치료효과，약물부반응소，사용안전교고。
Objective To evaluate the efficacy and safety of aripiprazole and sulpiride in treatment of schizophrenia negative symptoms. Methods 120 cases of schizophrenia whose predominant clin-ical features were negative symptoms were randomly assigned to treat with either aripiprezole or sulpiride for 3 months each. They were all assessed by SANS and TESS. Results There was a significant difference in efficacy between the groups assessed by SANS. Side effects of aripiprezole were significantly fewer than sulpiride assessed by TESS. Conclusions Aripiprazole has better ef-fect on schizophrenia whose negative symptoms as target symptom and less side effects.