CAJ | 학술논문

目的：研究培美曲塞联合奥沙利铂治疗晚期非小细胞肺癌（ NSCLC ）的临床疗效和安全性。方法NSCLC患者110例，随机分为培美曲塞联合奥沙利铂治疗组（研究组）及单纯培美曲塞治疗组（对照组）各55例，比较两种治疗方案的临床疗效及不良反应发生率。结果研究组疗效优于对照组（P＜0．05）。两组血红细胞下降、肌酐增高、呕吐、皮疹、过敏性反应的发生情况组间差异无统计学意义（P＞0．05）。研究组粒细胞下降、血小板下降、AST增高、恶心、疲乏、感觉异常的发生率均高于对照组，差异有统计学意义（ P＜0．05）。结论培美曲塞联合奥沙利铂治疗晚期NSCLC的临床疗效优于单纯培美曲塞治疗，但是不良反应较多，应注意控制。
목적：연구배미곡새연합오사리박치료만기비소세포폐암（ NSCLC ）적림상료효화안전성。방법NSCLC환자110례，수궤분위배미곡새연합오사리박치료조（연구조）급단순배미곡새치료조（대조조）각55례，비교량충치료방안적림상료효급불량반응발생솔。결과연구조료효우우대조조（P＜0．05）。량조혈홍세포하강、기항증고、구토、피진、과민성반응적발생정황조간차이무통계학의의（P＞0．05）。연구조립세포하강、혈소판하강、AST증고、악심、피핍、감각이상적발생솔균고우대조조，차이유통계학의의（ P＜0．05）。결론배미곡새연합오사리박치료만기NSCLC적림상료효우우단순배미곡새치료，단시불량반응교다，응주의공제。
Objective To study the efficacy and safety of pemetrexed combined with oxaliplatin in the treatment of advanced non-small cell lung cancer ( NSCLC ) .Methods One hundred and ten NSCLC patients were randomly divided into study group treated with pemetrexed combined with oxaliplatin and control group treated with pemetrexed alone,55 cases in each group .The clinical effect and the incidences of adverse reactions were compared between two groups.Results The effect of study group was better than that of control group (P<0.05).There were no significant differences in the incidences of decreased hemoglobin ,increased creatinine ,vomiting,rash,allergic reactions between two groups (P>0.05).The incidences of leukopenia ,thrombocytopenia,elevated AST,nausea,fatigue,feeling abnormal in the study group were higher than those in the control group (P<0.05).Conclusion The clinical effect of pemetrexed combined with oxaliplatin is superior to that of pemetrexed alone in the treatment of advanced NSCLC ,but it should pay attention to controlling a lot of adverse reactions .