CAJ | 학술논문

目的：探讨2型糖尿病患者肾微循环功能障碍、超敏C反应蛋白与心血管重构的关系。方法选取2型糖尿病患者73例，按是否合并肾脏微循环功能障碍分为肾脏微循环功能障碍组（40例）和无肾脏微循环功能障碍组（33例），另选取同期体检正常的健康者50例作为对照组。分别检测空腹血糖、餐后2 h 血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、尿素氮、肌酐、超敏C 反应蛋白（hs-CRP）；超声检测颈动脉内膜中层厚度（IMT）及斑块，心脏彩色多普勒测量左室舒张末内径、室间隔厚度、左室后壁厚度，计算左室重量指数（LVMI）。结果肾脏微循环功能障碍组LVMI、IMT、斑块积分、hs-CRP 水平显著高于无肾脏微循环功能障碍组，无肾脏微循环功能障碍组上述指标水平显著高于对照组（P ＜0．05）。结论 2型糖尿病患者心血管重构可能与肾微循环功能障碍、hs-CRP 升高有关。
목적：탐토2형당뇨병환자신미순배공능장애、초민C반응단백여심혈관중구적관계。방법선취2형당뇨병환자73례，안시부합병신장미순배공능장애분위신장미순배공능장애조（40례）화무신장미순배공능장애조（33례），령선취동기체검정상적건강자50례작위대조조。분별검측공복혈당、찬후2 h 혈당、총담고순、감유삼지、고밀도지단백、저밀도지단백、뇨소담、기항、초민C 반응단백（hs-CRP）；초성검측경동맥내막중층후도（IMT）급반괴，심장채색다보륵측량좌실서장말내경、실간격후도、좌실후벽후도，계산좌실중량지수（LVMI）。결과신장미순배공능장애조LVMI、IMT、반괴적분、hs-CRP 수평현저고우무신장미순배공능장애조，무신장미순배공능장애조상술지표수평현저고우대조조（P ＜0．05）。결론 2형당뇨병환자심혈관중구가능여신미순배공능장애、hs-CRP 승고유관。
Objective To explore the relationship of renal microcirculation function disorder and high -sensitivity C-reactive protein(hs-CRP) with cardiovascular remodeling in patients with type 2 diabetes mellitus.Methods Seventy-three cases of type 2 diabetes mellitus were divided into renal microcirculation function disorder group (40 cases) and non-renal microcirculation function disorder group (33 cases) based on whether complicated with renal microcirculation function disorder,and 50 healthy cases were enrolled in the control group .Fasting blood glucose,2-hour postprandial blood glucose, total cholesterol(TC),triglycerides,high density lipoprotein(HDL),low density lipoprotein(LDL),urea nitrogen,creatinine and hs-CRP were tested .The carotid intima-media thickness ( IMT ) and plaque were measured with ultrasound , left ventricular end diastolic diameter , interventricular septal thickness , left ventricular posterior wall were determined by Color Doppler echocardiography ,and left ventricular mass index (LVMI) was calculated.Results LVMI,IMT,plaque score and hs-CRP level in the renal microcirculation function disorder group were significantly higher than those in the non-renal microcirculation function disorder group , and the indexes above in the non-renal microcirculation function disorder group were significantly higher than the controls (P<0.05).Conclusion Cardiovascular remodeling might correlate with renal microcirculation function disorder and increased hs -CRP in patients with type 2 diabetes mellitus .