CAJ | 학술논문

目的：探讨H型高血压对冠心病患者左心室收缩功能的影响。方法选取2011年12月至2013年6月郑州大学第一附属医院心内科收治高血压合并冠心病患者为研究对象，将患者按照血同型半胱氨酸水平分为H型高血压组和单纯性高血压组，比较H型高血压组与单纯性高血压组中左心室收缩功能不全患者的比例及血脂、脑钠肽（BNP）情况。结果 H型高血压组左室收缩功能障碍患者的比例显著高于单纯高血压组（P＝0.002）；在Logistic回归分析中，H型高血压是左室收缩功能障碍的相关危险因素。结论 H型高血压与冠心病患者左室收缩功能障碍具有明显相关性，治疗冠心病患者时，常规控制血压的同时，降低同型半胱氨酸水平，可能会更有效降低冠心病患者心功能不全发生率，改善预后。
목적：탐토H형고혈압대관심병환자좌심실수축공능적영향。방법선취2011년12월지2013년6월정주대학제일부속의원심내과수치고혈압합병관심병환자위연구대상，장환자안조혈동형반광안산수평분위H형고혈압조화단순성고혈압조，비교H형고혈압조여단순성고혈압조중좌심실수축공능불전환자적비례급혈지、뇌납태（BNP）정황。결과 H형고혈압조좌실수축공능장애환자적비례현저고우단순고혈압조（P＝0.002）；재Logistic회귀분석중，H형고혈압시좌실수축공능장애적상관위험인소。결론 H형고혈압여관심병환자좌실수축공능장애구유명현상관성，치료관심병환자시，상규공제혈압적동시，강저동형반광안산수평，가능회경유효강저관심병환자심공능불전발생솔，개선예후。
Objective To investigate the effect of H type hypertension on left ventricular systolic function in patients with coronary heart disease. Methods One hundred patients with coronary heart dis-ease complicated with hypertension admitted and treated in the first affiliated hospital of Zhengzhou uni-versity from December 2011 to June 2013 were selected. According to different levels of homocysteine, they were divided into the H type hypertension group and the simple hypertension group. The proportion of patients with left ventricular systolic dysfunction and the levels of blood lipid,BNP of the two groups were compared. Results In H type hypertension group,the proportion of left ventricular dysfunction pa-tients was significantly higher than that in simple hypertension group( P=0 . 002 );In the Logistic regres-sion analysis,H type hypertension was a risk factor of reduced left ventricular systolic function. Conclu-sions H type hypertension is obviously correlated with coronary heart disease patients with reduced left ventricular systolic function. In the treatment of coronary heart disease patients,at the same time of rou-tine blood pressure control,reducing the level of Hcy,may be more effective on reducing the incidence of cardiac dysfunction in patients with coronary heart disease and improve their life quality.