CAJ | 학술논문

目的：分析急性髓系白血病（AML）患者诱导缓解化疗第7天微小残留白血病（MRD）检测与预后的关系。方法采用多参数流式细胞分析术对45例原发、初治成人 AML 患者于诱导缓解化疗第7天行 MRD 检测。结果化疗第7天 MRD <10-2患者1个疗程完全缓解（CR）率明显高于 MRD >10-2组患者（分别为85.7%和58.3%，P <0.05，差异有统计学意义）；对于化疗第7天 MRD >10-2者，适当延长化疗时间可提高1个疗程 CR 率（缓解率分别为66.7%和55.6%），但两者相比差异无统计学意义（P >0.05）。结论于诱导缓解化疗第7天行MRD 检测有助于 AML 预后的评估，同时为是否延长化疗时间提供依据。
목적：분석급성수계백혈병（AML）환자유도완해화료제7천미소잔류백혈병（MRD）검측여예후적관계。방법채용다삼수류식세포분석술대45례원발、초치성인 AML 환자우유도완해화료제7천행 MRD 검측。결과화료제7천 MRD <10-2환자1개료정완전완해（CR）솔명현고우 MRD >10-2조환자（분별위85.7%화58.3%，P <0.05，차이유통계학의의）；대우화료제7천 MRD >10-2자，괄당연장화료시간가제고1개료정 CR 솔（완해솔분별위66.7%화55.6%），단량자상비차이무통계학의의（P >0.05）。결론우유도완해화료제7천행MRD 검측유조우 AML 예후적평고，동시위시부연장화료시간제공의거。
Objective To analyze the relationship between minimal residual disease(MRD)de-tection in AML patients on seventh day of induction chemotherapy and prognosis. Methods The MRD was detected by multi-parameter flow cytometry in 45 cases of primary,newly diagnosed adult AML on seventh day of remission induction chemotherapy. Results Complete remission(CR)rate after the first course in MRD < 10-2 group was significantly higher than that in MRD > 10-2 group( 85. 7% and 58. 3% ,respectively,P < 0. 05,the difference had statistically significance);For patients in MRD > 10-2 group,prolonged the chemotherapy course for a few more days could improve the CR rate(remission rates were 66. 7% and 55. 6% ,but the difference was not statistically significant(,P > 0. 05). Conclu-sions Detection of MRD on seventh day of remission induction chemotherapy in AML is helpful in pre-dicting the prognosis,as well as providing the basis for prolonging chemotherapy.