中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
13期
65-66
,共2页
张静%孙玲%孟小莉%桑丽娜%闫春艳
張靜%孫玲%孟小莉%桑麗娜%閆春豔
장정%손령%맹소리%상려나%염춘염
急性髓系白血病%微小残留白血病检测%完全缓解率
急性髓繫白血病%微小殘留白血病檢測%完全緩解率
급성수계백혈병%미소잔류백혈병검측%완전완해솔
Acute myeloid leukemia%Minimal residual disease%Complete remission rate
目的:分析急性髓系白血病(AML)患者诱导缓解化疗第7天微小残留白血病(MRD)检测与预后的关系。方法采用多参数流式细胞分析术对45例原发、初治成人 AML 患者于诱导缓解化疗第7天行 MRD 检测。结果化疗第7天 MRD <10-2患者1个疗程完全缓解(CR)率明显高于 MRD >10-2组患者(分别为85.7%和58.3%,P <0.05,差异有统计学意义);对于化疗第7天 MRD >10-2者,适当延长化疗时间可提高1个疗程 CR 率(缓解率分别为66.7%和55.6%),但两者相比差异无统计学意义(P >0.05)。结论于诱导缓解化疗第7天行MRD 检测有助于 AML 预后的评估,同时为是否延长化疗时间提供依据。
目的:分析急性髓繫白血病(AML)患者誘導緩解化療第7天微小殘留白血病(MRD)檢測與預後的關繫。方法採用多參數流式細胞分析術對45例原髮、初治成人 AML 患者于誘導緩解化療第7天行 MRD 檢測。結果化療第7天 MRD <10-2患者1箇療程完全緩解(CR)率明顯高于 MRD >10-2組患者(分彆為85.7%和58.3%,P <0.05,差異有統計學意義);對于化療第7天 MRD >10-2者,適噹延長化療時間可提高1箇療程 CR 率(緩解率分彆為66.7%和55.6%),但兩者相比差異無統計學意義(P >0.05)。結論于誘導緩解化療第7天行MRD 檢測有助于 AML 預後的評估,同時為是否延長化療時間提供依據。
목적:분석급성수계백혈병(AML)환자유도완해화료제7천미소잔류백혈병(MRD)검측여예후적관계。방법채용다삼수류식세포분석술대45례원발、초치성인 AML 환자우유도완해화료제7천행 MRD 검측。결과화료제7천 MRD <10-2환자1개료정완전완해(CR)솔명현고우 MRD >10-2조환자(분별위85.7%화58.3%,P <0.05,차이유통계학의의);대우화료제7천 MRD >10-2자,괄당연장화료시간가제고1개료정 CR 솔(완해솔분별위66.7%화55.6%),단량자상비차이무통계학의의(P >0.05)。결론우유도완해화료제7천행MRD 검측유조우 AML 예후적평고,동시위시부연장화료시간제공의거。
Objective To analyze the relationship between minimal residual disease(MRD)de-tection in AML patients on seventh day of induction chemotherapy and prognosis. Methods The MRD was detected by multi-parameter flow cytometry in 45 cases of primary,newly diagnosed adult AML on seventh day of remission induction chemotherapy. Results Complete remission(CR)rate after the first course in MRD < 10-2 group was significantly higher than that in MRD > 10-2 group( 85. 7% and 58. 3% ,respectively,P < 0. 05,the difference had statistically significance);For patients in MRD > 10-2 group,prolonged the chemotherapy course for a few more days could improve the CR rate(remission rates were 66. 7% and 55. 6% ,but the difference was not statistically significant(,P > 0. 05). Conclu-sions Detection of MRD on seventh day of remission induction chemotherapy in AML is helpful in pre-dicting the prognosis,as well as providing the basis for prolonging chemotherapy.