CAJ | 학술논문

目的：观察白癜风患者表皮黑素细胞及真皮噬黑素细胞改变并探讨其意义。方法白癜风患者38例，分为寻常型进展期组、稳定期组，节段型进展期组及稳定期组。另选取同期整形外科手术的正常皮肤10例为正常对照组。采用免疫组化染色及常规病理 HE 染色，对 Melan-A 阳性细胞及真皮噬黑素细胞的数量进行统计分析。结果与正常对照组相比，白癜风各组 Melan-A 阳性细胞数量明显减少，噬黑素细胞数量明显增多，差异均有统计学意义（P <0.01）。白癜风各组别之间皮损 Melan-A 阳性细胞数差异无统计学意义（P >0.05）。同类型进展期组噬黑素细胞高于稳定期组，差异有统计学意义（P <0.01）。结论白癜风患者皮损中表皮黑素细胞明显减少，真皮噬黑素细胞明显增多，可能存在黑素细胞的真皮丢失途径。
목적：관찰백전풍환자표피흑소세포급진피서흑소세포개변병탐토기의의。방법백전풍환자38례，분위심상형진전기조、은정기조，절단형진전기조급은정기조。령선취동기정형외과수술적정상피부10례위정상대조조。채용면역조화염색급상규병리 HE 염색，대 Melan-A 양성세포급진피서흑소세포적수량진행통계분석。결과여정상대조조상비，백전풍각조 Melan-A 양성세포수량명현감소，서흑소세포수량명현증다，차이균유통계학의의（P <0.01）。백전풍각조별지간피손 Melan-A 양성세포수차이무통계학의의（P >0.05）。동류형진전기조서흑소세포고우은정기조，차이유통계학의의（P <0.01）。결론백전풍환자피손중표피흑소세포명현감소，진피서흑소세포명현증다，가능존재흑소세포적진피주실도경。
Objective To observe the changes of epidermal melanocytes and dermal melanoph-ages in vitiligo and investigate its significance. Methods Thirty-eight cases of vitiligo were divided into progressive stage group,stable stage group in nonsegmental vitiligo patients,and progressive stage group, stable stage group in segmental vitiligo patients. Normal controls of 10 cases were selected from the plas-tic surgery deparment in the same period. Melan-A positive cells and dermal melanophages were deter-mined by immunohistochemical staining and HE staining. Results Compared with normal controls,Me-lan-A positive cells counts were apparently lower and melanophages counts were higher in each vitiligo groups than those of normal controls,the differences were significant(P < 0. 01). No significant differ-ences were found among vitiligo groups(P > 0. 05). Melanophages counts of each vitiligo groups in pro-gressive stage were significantly higher than those of stable stage,the differences were significant(P <0. 01). Conclusions Apparently decreased counts of epidermal melanocytes and increased counts of dermal melanophages are found in vitiligo lesions. The lost of melanocytes from dermal pathway may par-ticipate in the pathogenesis of vitiligo.