中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
13期
12-14
,共3页
陈思潮%洪云峰%蔡华新%郭文若%陈文博%陈志杰%黄灿华%石成峰
陳思潮%洪雲峰%蔡華新%郭文若%陳文博%陳誌傑%黃燦華%石成峰
진사조%홍운봉%채화신%곽문약%진문박%진지걸%황찬화%석성봉
胃癌%腹腔游离癌细胞%术中及术后早期腹腔热低渗灌注化疗
胃癌%腹腔遊離癌細胞%術中及術後早期腹腔熱低滲灌註化療
위암%복강유리암세포%술중급술후조기복강열저삼관주화료
Gastric cancer%Exfoliated cancer cell%Therapy of intraoperative hypotonic peritoneal chemo-hyperthermia and early postoperative intraperitoneal chemotherapy
目的：探讨术中即时低渗温热腹腔化疗联合术后早期腹腔化疗的应用价值，并研究其应用方法。方法将 T4a、T4b 期胃癌82例患者随机分成术中即时低渗温热腹腔化疗联合术后早期腹腔化疗组（治疗组）与未行腹腔化疗组（对照组）。两组术后3~4周全身化疗，SP 方案（S1+ DDP）每3周1次，共6次。结果治疗组2年生存率为83.78%，对照组为61.76%，两组比较差异有统计学意义（P =0.001）；治疗组的3年生存率为70.27%，明显高于对照组（47.06%），两组比较差异有统计学意义（P =0.002）；治疗组肝转移的发生率为8.82%，明显低于对照组的32.35%，两组比较差异有统计学意义（P <0.01）。结论术中及术后早期腹腔温热灌注化疗可提高进展期胃癌生存率，减少肝转移率，是一种安全有效的治疗方法。
目的：探討術中即時低滲溫熱腹腔化療聯閤術後早期腹腔化療的應用價值，併研究其應用方法。方法將 T4a、T4b 期胃癌82例患者隨機分成術中即時低滲溫熱腹腔化療聯閤術後早期腹腔化療組（治療組）與未行腹腔化療組（對照組）。兩組術後3~4週全身化療，SP 方案（S1+ DDP）每3週1次，共6次。結果治療組2年生存率為83.78%，對照組為61.76%，兩組比較差異有統計學意義（P =0.001）；治療組的3年生存率為70.27%，明顯高于對照組（47.06%），兩組比較差異有統計學意義（P =0.002）；治療組肝轉移的髮生率為8.82%，明顯低于對照組的32.35%，兩組比較差異有統計學意義（P <0.01）。結論術中及術後早期腹腔溫熱灌註化療可提高進展期胃癌生存率，減少肝轉移率，是一種安全有效的治療方法。
목적：탐토술중즉시저삼온열복강화료연합술후조기복강화료적응용개치，병연구기응용방법。방법장 T4a、T4b 기위암82례환자수궤분성술중즉시저삼온열복강화료연합술후조기복강화료조（치료조）여미행복강화료조（대조조）。량조술후3~4주전신화료，SP 방안（S1+ DDP）매3주1차，공6차。결과치료조2년생존솔위83.78%，대조조위61.76%，량조비교차이유통계학의의（P =0.001）；치료조적3년생존솔위70.27%，명현고우대조조（47.06%），량조비교차이유통계학의의（P =0.002）；치료조간전이적발생솔위8.82%，명현저우대조조적32.35%，량조비교차이유통계학의의（P <0.01）。결론술중급술후조기복강온열관주화료가제고진전기위암생존솔，감소간전이솔，시일충안전유효적치료방법。
Objective To investigate the application value of combined therapy of intraoperative hypotonic peritoneal chemo-hyperthermia and early postoperative intraperitoneal chemotherapy on gastric cancer. Methods Eighty-two T4a and T4b stage gastric cancer patients were randomly divided into two groups,and patients in the treatment group underwent the combined therapy,and only peritoneal lavage with distilled water was given for patients in control group. Patients in both groups accepted vein chemo-therapy with SP scheme after operation. Results The overall 2-year survival rate of the therapy group and the control group was 83. 78% and 61. 76% ,respectively,there was significant difference between the two groups(P = 0. 001). The overall 3-year survival rate of the treatment group was 70. 27% ,which was significantly higher than that in the control group(47. 06% ),there was significant difference be-tween the two groups( P = 0. 002). The rate of liver metastasis in treatment group was 8. 82% and 32. 35% in control group,the difference was significant(P < 0. 01). Conclusions The combined appli-cation of intraoperative hypotonic chemo-hyperthermia and early postoperatively intraperitoneal chemother-apy is effective for gastric cancer. Intraperitoneal chemotherapy can be used to prevent liver metastasis for postoperative gastric cancer patients.
