CAJ | 학술논문

目的：探讨变应性支气管肺曲霉菌病的治疗方法，分析其临床特点。方法选取12例变应性支气管肺曲霉菌病患者做为研究对象，血清学阳性患者（ABPA-S）与伴中心型支气管扩张患者（ABPA-CB）各6例，两组患者均给予相应的治疗后，分析和比较两组患者的肺功能、嗜酸性粒细胞计数、白细胞计数、血清总 IgE。结果ABPA-S 组与 ABPA-CB 组在白细胞计数和一氧化碳弥散量（DLCO）占预计值百分比方面比较差异均无统计学意义（P >0.05），ABPA-CB 组的嗜酸性粒细胞计数与血清总 IgE 均要明显高于 ABPA-S 组（P <0.05），在1 s 用力呼气量（FEV1）占预计值百分比中 ABPA-S 组明显高于 ABPA-CB 组（P <0.05）。结论治疗变应性支气管肺曲霉菌病应结合临床分析，对于血清 IgE 升高的变应性支气管肺曲霉菌病患者考虑可能是早期，或者是侵袭性较弱的时候，可以采用伊曲康唑与糖皮质激素进行治疗。
목적：탐토변응성지기관폐곡매균병적치료방법，분석기림상특점。방법선취12례변응성지기관폐곡매균병환자주위연구대상，혈청학양성환자（ABPA-S）여반중심형지기관확장환자（ABPA-CB）각6례，량조환자균급여상응적치료후，분석화비교량조환자적폐공능、기산성립세포계수、백세포계수、혈청총 IgE。결과ABPA-S 조여 ABPA-CB 조재백세포계수화일양화탄미산량（DLCO）점예계치백분비방면비교차이균무통계학의의（P >0.05），ABPA-CB 조적기산성립세포계수여혈청총 IgE 균요명현고우 ABPA-S 조（P <0.05），재1 s 용력호기량（FEV1）점예계치백분비중 ABPA-S 조명현고우 ABPA-CB 조（P <0.05）。결론치료변응성지기관폐곡매균병응결합림상분석，대우혈청 IgE 승고적변응성지기관폐곡매균병환자고필가능시조기，혹자시침습성교약적시후，가이채용이곡강서여당피질격소진행치료。
Objective To study the treatment method of allergic bronchopulmonary aspergillo-sis,and analyze the clinical characteristics. Methods The data of 12 patients with allergic bronchopul-monary aspergillosis were retrospectively analyzed. Among the 12 cases,there were 6 patients with sero-logical positive(ABPA-S)and 6 patients with central type bronchiectasis(ABPA-CB). The pulmonary function,eosinophil counts,white blood cell counts and serum total IgE levels of the two groups after treatment were analyzed and compared. Results There weren’t significant differences in the white blood cell counts or DLCO percentages between group ABPA-S and group ABPA-CB(P > 0. 05). The eosino-phil counts and serum total IgE levels of group ABPA-CB were obviously higher than those of group AB-PA-S(P < 0. 05). The FEV1 percentage of group ABPA-S was obviously higher than that of group ABPA-CB(P < 0. 05). Conclusions The treatment of allergic bronchopulmonary aspergillosis should be com-bined with clinical analysis,itraconazole and glucocorticoid can be used for patients with increased serum IgE level,indicating possibly early or weaker invasive allergic bronchopulmonary aspergillosis.