CAJ | 학술논문

目的：探讨食管鳞状细胞癌组织中 E-钙粘蛋白的表达情况，并分析其与食管鳞状细胞癌的临床病理及5年生存率的关系。方法233例患者均来自河南省林州市。利用组织微阵列技术，采用免疫组化 ABC 法，分析233例食管鳞癌组织（观察组）和相应正常黏膜组织（对照组）中 E-钙粘蛋白表达情况。结果食管鳞癌组织中 E-钙粘蛋白的低表达阳性率高于正常食管黏膜组织中低表达阳性率（56.22% vs 39.29%，P <0.05）；食管鳞癌组织中 E-钙粘蛋白的低表达与食管鳞癌的淋巴结转移、TNM 分期有关，与食管鳞癌的发病年龄、性别、癌细胞分化程度、癌组织大体类型无关；E-钙粘蛋白正常表达的食管鳞癌患者5年生存率明显高于 E-钙粘蛋白低表达的食管鳞癌患者。结论 E-钙粘蛋白的低表达可能与食管鳞癌的发生、发展、转移相关，检测 E-钙粘蛋白可能为判断食管鳞癌的预后提供参考依据。
목적：탐토식관린상세포암조직중 E-개점단백적표체정황，병분석기여식관린상세포암적림상병리급5년생존솔적관계。방법233례환자균래자하남성림주시。이용조직미진렬기술，채용면역조화 ABC 법，분석233례식관린암조직（관찰조）화상응정상점막조직（대조조）중 E-개점단백표체정황。결과식관린암조직중 E-개점단백적저표체양성솔고우정상식관점막조직중저표체양성솔（56.22% vs 39.29%，P <0.05）；식관린암조직중 E-개점단백적저표체여식관린암적림파결전이、TNM 분기유관，여식관린암적발병년령、성별、암세포분화정도、암조직대체류형무관；E-개점단백정상표체적식관린암환자5년생존솔명현고우 E-개점단백저표체적식관린암환자。결론 E-개점단백적저표체가능여식관린암적발생、발전、전이상관，검측 E-개점단백가능위판단식관린암적예후제공삼고의거。
Objective To investigate the role of E-Cadherin,in the development and progres-sion of human esophageal squamous cell carcinoma(ESCC),and its relationship with the clinicopatho-logic characteristics and five-year survival rate of the patients. Methods The expression levels of E-Cadherin were detected in 233 ESCC tissues and their corresponding normal esophageal mucosal tissues by tissue array and immunohistochemistry. Results ESCC tissues showed a significantly higher low ex-pression rate of E-Cadherin than their corresponding normal esophageal mucosal tissues(56. 22% vs 39. 29% ,P < 0. 05). The low expression of E-Cadherin was correlated with lymph node metastasis and TMN stage,but not with the patients’age,gender,tumor differentiation and general classification. Sur-vival analysis showed that abnormal expression of E-Cadherin was correlated with the 5-year survival rate of patients with ESCC. Conclusions The abnormal expression of E-Cadherin may play an important role in the progression of ESCC,and detection of E-Cadherin expression may have important prognostic value.