临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014年
13期
1114-1116
,共3页
结肠癌%中性粒细胞%淋巴细胞%比率
結腸癌%中性粒細胞%淋巴細胞%比率
결장암%중성립세포%림파세포%비솔
Colon cancer%Prognosis%Neutrophils%Lymphocytes
目的：探讨中性粒细胞与淋巴细胞比率（NLR）变化对结肠癌患者生存率的预测价值。方法选择结肠癌患者124例进行随访研究，动态观察术前、术后化疗前、化疗后3月外周血 NLR 水平变化。对患者进行随访，记录随访结果并分析。结果术前外周静脉血 NLR 范围1.21~5.20，中位数2.95，术后化疗前复查 NLR 中位数3.02（1.45~5.34），以 NLR≥3.82为切值，5例患者 NLR 出现升高（≥3.82）；化疗后复查中位数2.81（1.13~4.98），有7例患者出现 NLR 下降（﹤3.82），下降率为26.93%（7/26）。术前高 NLR 患者3年、5年无复发生存率为60.4%、53.6%，显著低于低 NLR 患者（80.4%、72.5%）（log - rank χ2＝8.53，P ＝0.021）。术后化疗高 NLR 患者的3年、5年无复发生存率为56.8%、50.3%，显著低于低 NLR 患者（82.9%、76.5%）（log - rank χ2＝9.25，P ＝0.013）。化疗后3个月高 NLR 患者的3年、5年无复发生存率为61.2%、54.9%，显著低于低 NLR 患者（78.6%、70.4%）（log - rank χ2＝7.95，P ＝0.028）。结论 NLR 的动态水平变化可以作为结肠癌患者极有价值的预测指标。
目的：探討中性粒細胞與淋巴細胞比率（NLR）變化對結腸癌患者生存率的預測價值。方法選擇結腸癌患者124例進行隨訪研究，動態觀察術前、術後化療前、化療後3月外週血 NLR 水平變化。對患者進行隨訪，記錄隨訪結果併分析。結果術前外週靜脈血 NLR 範圍1.21~5.20，中位數2.95，術後化療前複查 NLR 中位數3.02（1.45~5.34），以 NLR≥3.82為切值，5例患者 NLR 齣現升高（≥3.82）；化療後複查中位數2.81（1.13~4.98），有7例患者齣現 NLR 下降（﹤3.82），下降率為26.93%（7/26）。術前高 NLR 患者3年、5年無複髮生存率為60.4%、53.6%，顯著低于低 NLR 患者（80.4%、72.5%）（log - rank χ2＝8.53，P ＝0.021）。術後化療高 NLR 患者的3年、5年無複髮生存率為56.8%、50.3%，顯著低于低 NLR 患者（82.9%、76.5%）（log - rank χ2＝9.25，P ＝0.013）。化療後3箇月高 NLR 患者的3年、5年無複髮生存率為61.2%、54.9%，顯著低于低 NLR 患者（78.6%、70.4%）（log - rank χ2＝7.95，P ＝0.028）。結論 NLR 的動態水平變化可以作為結腸癌患者極有價值的預測指標。
목적：탐토중성립세포여림파세포비솔（NLR）변화대결장암환자생존솔적예측개치。방법선택결장암환자124례진행수방연구，동태관찰술전、술후화료전、화료후3월외주혈 NLR 수평변화。대환자진행수방，기록수방결과병분석。결과술전외주정맥혈 NLR 범위1.21~5.20，중위수2.95，술후화료전복사 NLR 중위수3.02（1.45~5.34），이 NLR≥3.82위절치，5례환자 NLR 출현승고（≥3.82）；화료후복사중위수2.81（1.13~4.98），유7례환자출현 NLR 하강（﹤3.82），하강솔위26.93%（7/26）。술전고 NLR 환자3년、5년무복발생존솔위60.4%、53.6%，현저저우저 NLR 환자（80.4%、72.5%）（log - rank χ2＝8.53，P ＝0.021）。술후화료고 NLR 환자적3년、5년무복발생존솔위56.8%、50.3%，현저저우저 NLR 환자（82.9%、76.5%）（log - rank χ2＝9.25，P ＝0.013）。화료후3개월고 NLR 환자적3년、5년무복발생존솔위61.2%、54.9%，현저저우저 NLR 환자（78.6%、70.4%）（log - rank χ2＝7.95，P ＝0.028）。결론 NLR 적동태수평변화가이작위결장암환자겁유개치적예측지표。
Objective To explore the predictive value of neutrophil and lymphocyte ratio(NLR)for survival rate in patients with colon cancer. Methods A total of 124 patients with colon cancer were followed up before surgery,postoperative period before chemotherapy and 3 months after chemotherapy. Levels of NLR in peripheral blood were continuously observed. All patients were followed up and their results were re-corded and analyzed. Results The median peripheral blood NLR before surgery was 2. 95(1. 21 ~ 5. 20). The postoperative median NLR before chemotherapy was 3. 02(ranged from 1. 45 to 5. 34 ). According to the standard of NLR ≥ 3. 82,NLR had been elevated in 5 patients(≥3. 82). After chemotherapy,the median value of NLR was 2. 81(ranged from 1. 13 to 4. 98 ). The value of NLR in 7 patients had been decreased ( ﹤ 3. 82 )with the decrease rate of 26. 93%( 7 / 26 ). The 3 years and 5 years recurrence - free survival rates in patients with high preopera-tive NLR were 60. 4 % and 53. 6 % respectively,they were significantly lower than those of low NLR patients(80. 4% ,72. 5% )(log - rank χ2= 8. 53,P = 0. 021). The 3 years and 5 years recurrence - free survival rates in patients with high postoperative NLR before chemotherapy were 56. 8 % and 50. 3% respectively,they were significantly lower than those of low NLR patients(82. 9% ,76. 5% )(log - rank χ2 = 9. 25,P =0. 013). The 3 years and 5 years recurrence - free survival rates in patients with high NLR in 3 months after chemotherapy were 61. 2% and 54. 9% respectively,they were significantly lower than those of low NLR patients(78. 6% ,70. 4% )(log - rank χ2 = 7. 95,P = 0. 028). Conclu-sion The dynamic change in levels of NLR can be served as a valuable predictor in patients with colon cancer.
