CAJ | 학술논문

目的：探讨宫颈黏液抗精子抗体联合性交试验的联合检测对不孕症患者的检测意义。方法选106例女性血清抗精子抗体（AsAb）阳性不孕症患者，对其进行排卵期性交试验并测定宫颈黏液抗精子抗体，评估生殖道局部可能存在的免疫因素。结果血清 AsAb 阳性与宫颈黏液抗精子抗体、性交试验之间存在不一致性，宫颈黏液抗精子抗体以 IgA 为主，阳性率68.87%，宫颈黏液 AsAb - IgG 阳性率15.09%，二者比较差异有显著性（ P ﹤0.05）。血清 AsAb阳性、宫颈黏液 AsAb - IgA 阳性、性交试验阳性的41例患者中，32例为继发性不孕，占78.05%。血清 AsAb 阳性、宫颈黏液 AsAb - IgA 阳性、性交试验阴性或异常的32例患者中，22例为原发性不孕，占68.75%。结论测定血清 AsAb 并不能完全反映宫颈黏液抗精子抗体的状况，检测宫颈黏液 AsAb - IgA 较 AsAb - IgG 更有意义，宫颈黏液 AsAb - IgA、性交试验联合检测有助于评估女性生殖道局部可能存在的免疫因素。
목적：탐토궁경점액항정자항체연합성교시험적연합검측대불잉증환자적검측의의。방법선106례녀성혈청항정자항체（AsAb）양성불잉증환자，대기진행배란기성교시험병측정궁경점액항정자항체，평고생식도국부가능존재적면역인소。결과혈청 AsAb 양성여궁경점액항정자항체、성교시험지간존재불일치성，궁경점액항정자항체이 IgA 위주，양성솔68.87%，궁경점액 AsAb - IgG 양성솔15.09%，이자비교차이유현저성（ P ﹤0.05）。혈청 AsAb양성、궁경점액 AsAb - IgA 양성、성교시험양성적41례환자중，32례위계발성불잉，점78.05%。혈청 AsAb 양성、궁경점액 AsAb - IgA 양성、성교시험음성혹이상적32례환자중，22례위원발성불잉，점68.75%。결론측정혈청 AsAb 병불능완전반영궁경점액항정자항체적상황，검측궁경점액 AsAb - IgA 교 AsAb - IgG 경유의의，궁경점액 AsAb - IgA、성교시험연합검측유조우평고녀성생식도국부가능존재적면역인소。
Objective To explore the significance of cervical mucus anti - sperm antibody(AsAb)test combined with postcoital test for detecting infertility. Methods A total of 106 female infertile patients with positive serum AsAb test were enrolled in this study. Postcoital test and cervical mucus AsAb detection were examined near ovulation phase in order to assess the possible presence of vaginal immune factors. Results There was inconsistency among serum AsAb test,cervical mucus AsAb test and postcoital test. Cervical mucus AsAb test was mainly demonstrated positive IgA,and its positive rate was 68. 87% ,meanwhile,the positive rate of AsAb - IgG was 15. 09% ,there was significant difference( P ﹤0. 05). Forty one patients were tested for positive serum AsAb and positive cervical mucus AsAb - IgA and positive postcoital test. Among these 41 patients,32 were suffered from secondary infertility,accounted for 78. 05% . 32 patients were tested for positive serum AsAb and positive cervical mucus AsAb - IgA and negative postcoital test,including 22 cases suffered from primary infertility,accounted for 68. 75% . Conclusion The de-termination of cervical mucus AsAb does not represent the condition of serum AsAb test. The detection of cervical mucus AsAb - IgA is more sensi-tive than AsAb - IgG. Cervical mucus AsAb - IgA test combined with postcoital test may be an effective way to assess immune factors in female re-productive tract.