CAJ | 학술논문

采用饱和水溶液法进行包合，利用紫外分光光度法进行物相鉴别以及用烘箱进行热稳定性实验。研究了β-环糊精包合钩藤碱的最佳工艺并对包合物稳定性进行初步研究。结果表明：经紫外分光光度法鉴定，表明钩藤碱-β-环糊精确已形成包合物，其条件是钩藤碱与β-CD比为1：7，乙醇最佳浓度为80％，包合最佳时间为15 min。热稳定性实验对包合物的稳定进行测定，表明了钩藤碱β-CD包合物的热稳定性明显优于混合物。本试验中当钩藤碱与β-CD形成包合物以后能明显提高稳定性，采用饱和水溶液法制备的钩藤碱β-CD包合物操作简便，成本低，对设备要求不高，且稳定性好，具有一定推广应用价值。
채용포화수용액법진행포합，이용자외분광광도법진행물상감별이급용홍상진행열은정성실험。연구료β-배호정포합구등감적최가공예병대포합물은정성진행초보연구。결과표명：경자외분광광도법감정，표명구등감-β-배호정학이형성포합물，기조건시구등감여β-CD비위1：7，을순최가농도위80％，포합최가시간위15 min。열은정성실험대포합물적은정진행측정，표명료구등감β-CD포합물적열은정성명현우우혼합물。본시험중당구등감여β-CD형성포합물이후능명현제고은정성，채용포화수용액법제비적구등감β-CD포합물조작간편，성본저，대설비요구불고，차은정성호，구유일정추엄응용개치。
Using saturated aqueous solution method , phase identification was carried out with UV spectrophotometry and thermal stability was tested with oven.The optimum process and stability of β-cyclodextrin rhynchophylline were preliminarily studied.The results showed that the identification by UV spectrophotometry indicated Rhy -β-cyclodextrin inclusion complex indeed , with the proviso that Rhy β-CD ratio of 1:7 , the optimal concentration of ethanol was 80%and the best time was 15 min.Thermal stability test on the stability of inclusion complexes were determined , which showed rhynchophylline β-CD inclusion complex mixture had superior thermal stability.The rhynchophylline form the inclusion complexes with β-CD can significantly improve the stability.The use of a saturated aqueous solution prepared rhynchophylline β-CD inclusion complex was simple , low cost, less demanding on the equipment , and the stability was good, with a certain application value.