CAJ | 학술논문

以对硝基甲苯作为原料，针对传统的溴素制备氢溴酸上溴工艺，改进溴化剂，引入N-溴代丁二酰亚胺（ NBS ）作为溴化剂，偶氮二异丁腈（ AIBN）作为引发剂，二氯甲烷作为最佳反应溶剂，50℃反应8 h，反应收率≥85％。该工艺路线具有生产成本低、操作简便、反应时间短、适合工业化生产以及符合环保要求等特点。
이대초기갑분작위원료，침대전통적추소제비경추산상추공예，개진추화제，인입N-추대정이선아알（ NBS ）작위추화제，우담이이정정（ AIBN）작위인발제，이록갑완작위최가반응용제，50℃반응8 h，반응수솔≥85％。해공예로선구유생산성본저、조작간편、반응시간단、괄합공업화생산이급부합배보요구등특점。
A new method of preparation 4 -nitrobenzyl bromide was developed using p -nitrotoluene as raw material, NBS as bromination agent and AIBN as initiator , with the optimum solvent methylene chloride , reaction temperature 50 ℃, reaction time 8 h, and the yield was up to 85%.The method of the basis of traditional process of bromine bromine preparation hydrobromide improved agent bromide.This process route had the characteristics of a low production cost , simple operation , short reaction time , easy industrial production and environmentally friendly.