CAJ | 학술논문

采用结扎冠状动脉左前降支造成心肌缺血损伤模型，研究N-（4-胍基丁基）阿魏酰胺（ Feruloylagmatine， FLM）对冠脉结扎所致大鼠急性心肌缺血的保护作用，并探讨作用机制。结果表明：连续给药7天后， FLM 2.46、4.92、9.84 mg/kg能明显减小模型大鼠心肌梗死面积，抑制心电图S-T段抬高，提高血清超氧化物歧化酶（ SOD）活性，降低丙二醛（ MDA）含量和乳酸脱氢酶（ LDH）、肌酸激酶（ CK）活性，改善大鼠心肌病理组织学变化，对结扎大鼠冠状动脉所致急性心肌缺血损伤具有明显的保护作用，其作用与抗氧化有关。
채용결찰관상동맥좌전강지조성심기결혈손상모형，연구N-（4-고기정기）아위선알（ Feruloylagmatine， FLM）대관맥결찰소치대서급성심기결혈적보호작용，병탐토작용궤제。결과표명：련속급약7천후， FLM 2.46、4.92、9.84 mg/kg능명현감소모형대서심기경사면적，억제심전도S-T단태고，제고혈청초양화물기화매（ SOD）활성，강저병이철（ MDA）함량화유산탈경매（ LDH）、기산격매（ CK）활성，개선대서심기병리조직학변화，대결찰대서관상동맥소치급성심기결혈손상구유명현적보호작용，기작용여항양화유관。
The protective effect of Feruloylagmatine ( FLM ) on experimental myocardial infarction in rat and its mechanism were studied by ligating the left anterior descending coronary artery.Before infracted 24 h, rat were treated with FLM in a dosage of 2.46, 4.92, 9.84 mg/kg p.o., myocardial infarction size were significantly reduced , so were the CK, MDA and LDH, ECG S -T segment elevation were inhibited , SOD activity was increased markedly , rat myocardial histopathological changes were improved.FLM can significantly protect the acute ischemic injury by anti -oxygen.