CAJ | 학술논문

目的：评价两性霉素 B 与伏立康唑两种抗真菌药物在急性淋巴细胞白血病合并侵入性真菌感染治疗中的疗效及安全性。方法96例急性淋巴细胞白血病并发侵袭性细菌感染患者，根据不同抗真菌治疗药物分成两组，两性霉素 B 治疗组（n =40）和伏立康唑治疗组（n =56），观察两组患者的临床疗效和不良反应。结果两性霉素 B 组的总有效率为77.5%（31/40），药物相关的不良反应发生率为62.5%（25/40）；伏立康唑组的总有效率为92.8%（52/56），不良反应发生率为16.1%（9/56）；两组有效率和不良反应发生率比较差异均有统计学意义（P <0.05）。结论两种药物对急性淋巴细胞白血病合并侵袭性真菌感染的患者均有效，且伏立康唑治疗血液系统恶性肿瘤并发侵袭性真菌感染的疗效更加确切，不良反应发生率更低。
목적：평개량성매소 B 여복립강서량충항진균약물재급성림파세포백혈병합병침입성진균감염치료중적료효급안전성。방법96례급성림파세포백혈병병발침습성세균감염환자，근거불동항진균치료약물분성량조，량성매소 B 치료조（n =40）화복립강서치료조（n =56），관찰량조환자적림상료효화불량반응。결과량성매소 B 조적총유효솔위77.5%（31/40），약물상관적불량반응발생솔위62.5%（25/40）；복립강서조적총유효솔위92.8%（52/56），불량반응발생솔위16.1%（9/56）；량조유효솔화불량반응발생솔비교차이균유통계학의의（P <0.05）。결론량충약물대급성림파세포백혈병합병침습성진균감염적환자균유효，차복립강서치료혈액계통악성종류병발침습성진균감염적료효경가학절，불량반응발생솔경저。
Objective To compare the clinical effects and securities of amphotericin B and vori-conazole in the treatment of patients with acute lymphoblastic leukemia complicated with invasive fungal infection. Methods Ninety-six patients suitable for the experiment were divided into amphotericin B group(n = 40)and voriconazole group(n = 56),and the clinical effects and securities between the two groups tvere compared. Results The total efficiency rate in amphotericin B group was 77. 5%(31 / 40), and the rate of drug-related adverse event was 62. 5%(25 / 40). However,the total efficiency rate was 92. 8%(52 / 56),and the incidence of drug-related adverse event was 16. 1%(9 / 56)in voriconazole group,there were significant differences between the two groups(P < 0. 05). Conclusions Amphoteri-cin B and voriconazole are both effective for patients with acute lymphoblastic leukemia complicated with invasive fungal infection,and voriconazole has better clinical effects and lower adverse event rate.