CAJ | 학술논문

目的：研究妊娠期糖尿病孕妇孕前体质量和孕晚期血脂水平与新生儿出生体质量的关系。方法选择正常糖耐量孕妇（对照组）和妊娠期糖尿病孕妇（妊娠期糖尿病组）各52例，采用日立7080型全自动生化分析仪测定血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和脂蛋白（a）[LP（a）]，同时记录两组孕妇的年龄、孕周、妊娠前体质量与新生儿出生体质量等。结果妊娠期糖尿病组孕前体质量、TG、LDL-C 均显著高于对照组，差异有统计学意义（P <0.05）。孕前体质量、TG 与新生儿出生体质量呈正相关（P <0.05），LP（a）与新生儿出生体质量呈负相关（P <0.05）。结论妊娠期糖尿病孕妇存在以 TG、LDL-C 升高为特点的高脂血症，与正常糖耐量孕妇相比，伴发了更为严重的血脂代谢异常，并明显影响着新生儿的出生体质量，因此对妊娠期糖尿病孕妇进行孕前体质量的控制、孕晚期血脂水平的监测和必要的饮食指导具有重要的临床意义。
목적：연구임신기당뇨병잉부잉전체질량화잉만기혈지수평여신생인출생체질량적관계。방법선택정상당내량잉부（대조조）화임신기당뇨병잉부（임신기당뇨병조）각52례，채용일립7080형전자동생화분석의측정혈청총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）화지단백（a）[LP（a）]，동시기록량조잉부적년령、잉주、임신전체질량여신생인출생체질량등。결과임신기당뇨병조잉전체질량、TG、LDL-C 균현저고우대조조，차이유통계학의의（P <0.05）。잉전체질량、TG 여신생인출생체질량정정상관（P <0.05），LP（a）여신생인출생체질량정부상관（P <0.05）。결론임신기당뇨병잉부존재이 TG、LDL-C 승고위특점적고지혈증，여정상당내량잉부상비，반발료경위엄중적혈지대사이상，병명현영향착신생인적출생체질량，인차대임신기당뇨병잉부진행잉전체질량적공제、잉만기혈지수평적감측화필요적음식지도구유중요적림상의의。
Objective To investigate the relationship of prepregnancy weight and lipid levels of late pregnancy in gestational diabetes mellitus(GDM)with neonatal birth weight. Methods Fifty-two normal glucose tolerance(NGT)pregnant women(control group)and 52 pregnant women with gestational diabetes mellitus( GDM group)were chose. Hitachi 7080 automatic biochemical analyzer was used to measure the serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol(LDL-C)and lipoprotein(a)[LP(a)]. At the same time, maternal age,gestational age,body weight before pregnancy and fetal birth weight were recorded in the two groups. Results Prepregnancy weight and the levels of TG and LDL-C were significantly higher in GDM group than those in control group(P <0. 01). Prepregnancy weight and the TG was postively correla-ted with neonatal birth weight(P <0. 05). The LP(a)was negatively correlated with neonatal birth weight (P <0. 05). Conclusions Hyperlipidemia including TG and LDL-C in pregnant women with gestational diabetes mellitus are elevated. Gestational diabetes compared with pregnant women with normal glucose tol-erance,has more serious abnormal lipid metabolism,and it significantly affect the neonatal birth weight. Therefore,it has important clinical significance of controling body weight before pregnancy and monitoring serum lipid levels in pregnancy and the necessary dietary guidance for women with gestational diabetes.