CAJ | 학술논문

垂体腺瘤为颅内良性肿瘤，但却是成年人脑肿瘤的第三大常见肿瘤，仅次于神经胶质瘤和脑膜瘤。垂体腺瘤定义为良性肿瘤，但部分垂体腺瘤可对周围组织有侵袭性，手术难以切除，术后易复发。RWD结构修饰增强子（RWD containing su-moylation enhancer，RSUME），可在垂体腺瘤中通过小泛素化（small ubiquitin related modifiers，SUMO）稳定缺氧诱导因子-1α（hy-poxia inducible factor-1α，HIF-1α）以及抑制分子kappaB（inhibitor kappaB，IκB）的活性，促进垂体腺瘤的侵袭作用。RSUME对垂体腺瘤的侵袭性起着重要的作用，但RSUME的作用与垂体腺瘤侵袭的相关性尚未明确。本文就RSUME对垂体腺瘤侵袭作用中HIF-1α/VEGF信号通路以及IκB/NF-κB复合体的作用进行综述。
수체선류위로내량성종류，단각시성년인뇌종류적제삼대상견종류，부차우신경효질류화뇌막류。수체선류정의위량성종류，단부분수체선류가대주위조직유침습성，수술난이절제，술후역복발。RWD결구수식증강자（RWD containing su-moylation enhancer，RSUME），가재수체선류중통과소범소화（small ubiquitin related modifiers，SUMO）은정결양유도인자-1α（hy-poxia inducible factor-1α，HIF-1α）이급억제분자kappaB（inhibitor kappaB，IκB）적활성，촉진수체선류적침습작용。RSUME대수체선류적침습성기착중요적작용，단RSUME적작용여수체선류침습적상관성상미명학。본문취RSUME대수체선류침습작용중HIF-1α/VEGF신호통로이급IκB/NF-κB복합체적작용진행종술。
Pituitary adenoma, a benign intracranial tumor, is the third most common brain tumor, second only to glioma and me-ningioma. Pituitary adenoma has been defined as a benign tumor, but some pituitary adenomas can invade the surrounding tissue. This tumor is difficult to resect and can easily recur after surgery. RWD-containing sumoylation enhancer (RSUME) can stabilize the activity of hypoxia-inducible factor-1α and inhibitor kappaB by the small ubiquitin-related modifiers. This phenomenon indicates the impor-tance of RSUME in pituitary adenoma because it promotes the invasiveness of the tumor. However, the correlation between RSUME and the invasion of pituitary adenoma remains unclear. In this study, the roles of RSUME on HIF-1α/VEGF signaling pathway and IκB/NF-κB compomers in the invasiveness of pituitary adenoma were reviewed.