CAJ | 학술논문

目的：观察粉防己甲素联合氟桂利嗪胶囊对偏头痛患者治疗效果及安全性。方法70例偏头痛患者随机分为对照组36例（氟桂利嗪胶囊）和治疗组34例（粉防己甲素片联合氟桂利嗪胶囊）。观察两组患者视觉模拟量表（VAS）评分、口述疼痛分级法（VRS）评分与生存质量评分（SF -36）变化。结果两组患者年龄、病程、治疗前 VAS、VRS 积分及 SF -36评分差异无统计学意义（ P ﹥0.05）。两组治疗后 VAS、VRS 积分均显著降低，治疗组优于对照组（ P ﹤0.05）。治疗组患者生活质量各维度评分较治疗前均有显著提高，差异有统计学意义（ P ﹤0.05）。对照组患者生理功能、生理职能、躯体疼痛、总体健康、精力及社会功能较治疗前比较有明显提高（ P ﹤0.05）。治疗后两组比较，治疗组各维度评分均高于对照组，其中生理职能、躯体疼痛及总体健康评分差异均有统计学意义（ P ﹤0.05）。结论粉防己甲素片能显著提高氟桂利嗪胶囊治疗偏头痛的临床效果，改善患者的生活质量，其作用机制有待进一步深入研究。
목적：관찰분방기갑소연합불계리진효낭대편두통환자치료효과급안전성。방법70례편두통환자수궤분위대조조36례（불계리진효낭）화치료조34례（분방기갑소편연합불계리진효낭）。관찰량조환자시각모의량표（VAS）평분、구술동통분급법（VRS）평분여생존질량평분（SF -36）변화。결과량조환자년령、병정、치료전 VAS、VRS 적분급 SF -36평분차이무통계학의의（ P ﹥0.05）。량조치료후 VAS、VRS 적분균현저강저，치료조우우대조조（ P ﹤0.05）。치료조환자생활질량각유도평분교치료전균유현저제고，차이유통계학의의（ P ﹤0.05）。대조조환자생리공능、생리직능、구체동통、총체건강、정력급사회공능교치료전비교유명현제고（ P ﹤0.05）。치료후량조비교，치료조각유도평분균고우대조조，기중생리직능、구체동통급총체건강평분차이균유통계학의의（ P ﹤0.05）。결론분방기갑소편능현저제고불계리진효낭치료편두통적림상효과，개선환자적생활질량，기작용궤제유대진일보심입연구。
Objective To observe the effect of Tetrandrine tablets for treatment of migraine. Methods 70 patients were randomly divid-ed into control group(36 patients treated with Flunarizine capsules)and treatment group(34 patients received Tetrandrine Tablets plus Flunariz-ine capsules). Visual Analogue Scale,Verbal Rating Scale and SF - 36 scale were used to evaluate the effects of this medicine. Results There were no significant difference in two groups of patients among ages,courses of the disease,scores of VAS or VRS,and SF - 36 respectively( P﹥ 0. 05). The scores of VAS and VRS were reduced significantly after treating in two groups. And the scores were lower in treatment group than that of control group after the treatment( P ﹤ 0. 05). Every dimension scores of Quality of life were significantly improved in treatment group. The differences were statistically significant( P ﹤ 0. 05). The scores of physic functioning,role - physical,body pain,general health,vitality and so-cial function were improved after the treatment in control group( P ﹤ 0. 05). Compared in the two groups after treatment,the scores of role -physical,body pain and general health in treatment group were higher than those in control group( P ﹤ 0. 05). And there were no significant difference among the others. Conclusion Tetrandrine tablets could be used to promote the effects of Flunarizine capsules on treating patients with migraine and improve the Quality of life(Qol)of patients. The mechanism should be explored in the future.