CAJ | 학술논문

目的：探讨血脂异常者血清单核细胞趋化蛋白- l（MCP -1）、血红素加氧酶-1（HO -1）、脂联素（APN）及肿瘤坏死因子α（TNF -α）水平的检测及临床价值。方法采用酶联免疫吸附法（ ELISA）检测85例血脂异常者和35例健康对照者血清 MCP -1、HO -1、APN 及 TNF -α的水平，同时检测血脂异常者血清其他脂类代谢指标[总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL - C）及高密度脂蛋白胆固醇（HDL - C）]的水平，并分析 MCP -1、HO -1、APN及 TNF -α与脂类代谢指标的相关性。结果血脂异常者血清 MCP -1、HO -1和 APN 水平较健康对照组均显著升高，差异具有统计学意义（ P ﹤0.01），而 TNF -α水平较健康对照组则明显降低，差异具有统计学意义（ P ﹤0.01）；同时血脂异常者血清 HO -1水平与 MCP -1及 LDL - C 水平均呈正相关关系；APN 水平则与 TNF -α呈负相关关系，与 LDL - C 水平呈正相关关系；而健康对照组的 HO -1水平与 MCP -1水平无明显关系。结论血脂异常者血清 MCP -1、HO -1和 APN水平显著升高，而 TNF -α水平则明显降低，说明 MCP -1、HO -1、APN 及 TNF -α可能参与了动脉粥样硬化的发生及发展，并可能成为动脉粥样硬化潜在的预防或治疗靶点。
목적：탐토혈지이상자혈청단핵세포추화단백- l（MCP -1）、혈홍소가양매-1（HO -1）、지련소（APN）급종류배사인자α（TNF -α）수평적검측급림상개치。방법채용매련면역흡부법（ ELISA）검측85례혈지이상자화35례건강대조자혈청 MCP -1、HO -1、APN 급 TNF -α적수평，동시검측혈지이상자혈청기타지류대사지표[총담고순（TC）、삼선감유（TG）、저밀도지단백담고순（LDL - C）급고밀도지단백담고순（HDL - C）]적수평，병분석 MCP -1、HO -1、APN급 TNF -α여지류대사지표적상관성。결과혈지이상자혈청 MCP -1、HO -1화 APN 수평교건강대조조균현저승고，차이구유통계학의의（ P ﹤0.01），이 TNF -α수평교건강대조조칙명현강저，차이구유통계학의의（ P ﹤0.01）；동시혈지이상자혈청 HO -1수평여 MCP -1급 LDL - C 수평균정정상관관계；APN 수평칙여 TNF -α정부상관관계，여 LDL - C 수평정정상관관계；이건강대조조적 HO -1수평여 MCP -1수평무명현관계。결론혈지이상자혈청 MCP -1、HO -1화 APN수평현저승고，이 TNF -α수평칙명현강저，설명 MCP -1、HO -1、APN 급 TNF -α가능삼여료동맥죽양경화적발생급발전，병가능성위동맥죽양경화잠재적예방혹치료파점。
Objective To investigate the clinical value of serum levels of monoCyse chemoattractant protein -1(MCP -1),heme oxygenase-1(HO -1),adiponectin(APN)and tumor necrosis factor - α(TNF - α)in patients with dyslipidemia. Methods The serum levels of MCP -1,HO -1,APN and TNF - α were detected by using enzyme linked immunosorbent assay(ELISA)in 85 patients with dyslipidemia and 35 healthy controls. Meanwhile the serum levels of other lipid metabolism parameters including total cholesterol(TC),triglyceride(TG),low density lipopro-tein cholesterol(LDL - C)and high - density lipoprotein cholesterol(HDL - C)were also detected in patients with dyslipidemia. The correlation between the levels of lipid metabolism parameters and the levels of MCP -1,HO -1,APN and TNF - α was analyzed. Results The serum levels of MCP -1,HO -1,and APN in patients with dyslipidemia were significantly higher than those in healthy controls( P ﹤0. 01). Meanwhile the ser-um level of TNF - α in patients with dyslipidemia was significantly lower than that in healthy controls( P ﹤0. 01). The serum level of HO -1 in pa-tients with dyslipidemia was positively correlated with MCP -1 and LDL - C. The serum level of APN was negatively correlated with TNF - α ,but positively correlated with LDL - C. The serum level of HO -1 had no correlation with MCP -1 in healthy control group. Conclusion MCP -1,HO- 1,APN and TNF - α may participate in the occurrence and development of atherosclerosis and may be potential targets in the prevention and treat-ment of atherosclerosis.