CAJ | 학술논문

目的：探讨患者体内抗凝血酶-Ⅲ浓度与乙型肝炎肝硬化的严重程度的相关性，为病情诊断提供依据。方法从2012年1月至2013年7月间收治的乙型肝炎肝硬化患者中随机选取60例作为观察组，另从同期体检的健康人员中随机选取30例作为对照组，分别检测两组对象血浆中抗凝血酶-Ⅲ的含量。结果观察组患者血浆抗凝血酶-Ⅲ水平明显低于健康对照组（ P ﹤0.05），且 Child - Pugh 分级 A 级、B 级、C 级三组中抗凝血酶-Ⅲ水平逐级降低，A级、B 级、C 级各组之间比较差异均具有显著性（ P ﹤0.05）。结论血浆抗凝血酶-Ⅲ的检测水平与乙型肝炎肝硬化患者病情严重程度直接相关，临床可以根据血浆抗凝血酶-Ⅲ的检测水平判断患者病情，制定相应治疗对策。
목적：탐토환자체내항응혈매-Ⅲ농도여을형간염간경화적엄중정도적상관성，위병정진단제공의거。방법종2012년1월지2013년7월간수치적을형간염간경화환자중수궤선취60례작위관찰조，령종동기체검적건강인원중수궤선취30례작위대조조，분별검측량조대상혈장중항응혈매-Ⅲ적함량。결과관찰조환자혈장항응혈매-Ⅲ수평명현저우건강대조조（ P ﹤0.05），차 Child - Pugh 분급 A 급、B 급、C 급삼조중항응혈매-Ⅲ수평축급강저，A급、B 급、C 급각조지간비교차이균구유현저성（ P ﹤0.05）。결론혈장항응혈매-Ⅲ적검측수평여을형간염간경화환자병정엄중정도직접상관，림상가이근거혈장항응혈매-Ⅲ적검측수평판단환자병정，제정상응치료대책。
Objective To investigate the relationship of antithrombin - Ⅲ detection concentration and the severity of cirrhosis. Methods From our hospital between January 2012 to July 2013,60 liver cirrhosis patients were included into this study. All 60 cases were randomly se-lected as the observation group. The other 30 cases from the same period in our hospital for medical examination of health personnel were randomly selected as the control group. The plasma antithrombin - Ⅲ concentration in all these cases were detected. These results were analyzed and com-pared. Results The antithrombin - Ⅲ in cirrhosis patients were significantly lower than in healthy persons( P ﹤ 0. 05). The lower level of an-tithrombin - Ⅲ is in these patients,the more serious condition( P ﹤ 0. 05). Conclusion The detection of antithrombin - Ⅲ level in patients with liver cirrhosis is directly related to the severity of clinical. The antithrombin - Ⅲ detection level can be used to judge the patient′s condition and develop appropriate treatment strategies.