CAJ | 학술논문

目的：探讨晚期实体肿瘤患者凝血功能的变化。方法采集71例晚期实体肿瘤患者（晚期肿瘤组）与20例健康人（对照组）的静脉血，检测血小板、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、D -二聚体（D - Di-mer）和纤维蛋白原（Fbg）。结果晚期肿瘤组血小板数值较对照组明显升高，两组比较有显著性差异（ P ﹤0.01）。晚期肿瘤组较对照组 Fbg、D - Dimer 显著升高（ P ﹤0.01），APTT 显著缩短（ P ﹤0.05）。结论晚期实体肿瘤患者存在高凝状态，正确的抗凝治疗是必要的。
목적：탐토만기실체종류환자응혈공능적변화。방법채집71례만기실체종류환자（만기종류조）여20례건강인（대조조）적정맥혈，검측혈소판、응혈매원시간（PT）、활화부분응혈활매시간（APTT）、D -이취체（D - Di-mer）화섬유단백원（Fbg）。결과만기종류조혈소판수치교대조조명현승고，량조비교유현저성차이（ P ﹤0.01）。만기종류조교대조조 Fbg、D - Dimer 현저승고（ P ﹤0.01），APTT 현저축단（ P ﹤0.05）。결론만기실체종류환자존재고응상태，정학적항응치료시필요적。
Objective To clarify the changes of coagulation function in patients with advanced solid tumors. Methods A total of 71 pa-tients with advanced solid tumors and 20 healthy persons as controls were collected. Platelet count,prothrombin time( PT),activated partial thromboplastin time(APTT),D - Dimer and fibrinogen(Fbg)were detected. Results There was significantly increase of platelets in advanced solid tumors group compared to those of healthy control group;there was significant elevation of Fbg and D - Dimer and significantly shortened APTT in advanced solid tumors group compared to those of healthy control group. Conclusion Patients with advanced solid tumors exist in hyper-coagulable status and appropriate anticoagulation therapy should be applied.