CAJ | 학술논문

化学药物治疗（简称化疗）是目前治疗恶性肿瘤的主要手段之一，但肿瘤的多药耐药（multidurg resistance, MDR）是临床化疗失败的主要原因之一，然而肿瘤的耐药机制至今尚未被完全阐明。microRNA是近年来生命科学新的研究热点之一，microRNA通过在转录后水平调控基因表达而参与调控一系列的生命活动，包括细胞增殖、凋亡、脂肪代谢、神经元发育、激素分泌、肿瘤血管生成、干细胞分化、肿瘤细胞浸润及转移等多种生理和病理过程。最近的研究表明，microRNA对多基因表达的调控具有高效性和特异性，对靶基因的异常调控可能构成肿瘤耐药机制，是肿瘤耐药复杂性调控的重要构成部分。因此，对microRNA与肿瘤耐药性的研究具有现实意义。本文对近年来肿瘤耐药性的研究，microRNA调控肿瘤耐药机制及microRNA作为肿瘤耐药治疗潜在靶点作一综述。
화학약물치료（간칭화료）시목전치료악성종류적주요수단지일，단종류적다약내약（multidurg resistance, MDR）시림상화료실패적주요원인지일，연이종류적내약궤제지금상미피완전천명。microRNA시근년래생명과학신적연구열점지일，microRNA통과재전록후수평조공기인표체이삼여조공일계렬적생명활동，포괄세포증식、조망、지방대사、신경원발육、격소분비、종류혈관생성、간세포분화、종류세포침윤급전이등다충생리화병리과정。최근적연구표명，microRNA대다기인표체적조공구유고효성화특이성，대파기인적이상조공가능구성종류내약궤제，시종류내약복잡성조공적중요구성부분。인차，대microRNA여종류내약성적연구구유현실의의。본문대근년래종류내약성적연구，microRNA조공종류내약궤제급microRNA작위종류내약치료잠재파점작일종술。
Chemotherapy is one of the primary treatment for malignant tumors. Tumor multidrug resistance (MDR) is a major cause of clinical failure of chemotherapy;however the mechanisms of chemo-resistance have not been fully elucidated. Recently, microRNA is one of the new hotspots in life science. MicroRNA regulates the expression of genes and plays roles a series of life events by post-transcriptional regulations, including cell proliferation, apoptosis, fat metabolism, ner-vous development, hormone secretion, tumor vessels generation, stem cell differentiation, tumor cell invasion and metastasis, and other physiological and pathological processes. Recent studies show that microRNA regulates the expression of multiple genes with high efficiency and specificity. The abnormal regulation of target genes by microRNA is responsible for tumor chemo-resistance, this may be an important component of the complexity of the regulation of chemo-resistance. hTerefore, the study of microRNA and tumor drug resistance has profound practical signiifcance. In this review, recent studies of tumor drug resistance, regulation of tumor drug resistance by microRNA, and microRNA as a potential target for tumor drug resistance therapy are reviewed.