CAJ | 학술논문

背景与目的胸腔镜治疗早期肺癌在预后方面取得与传统开胸手术方式相同的效果，患者在这两种术式术后恢复方面是否存在差别是最近研究的热点。本研究旨在探讨胸腔镜治疗早期周围型肺癌根治术患者机体术后炎性状态变化。方法选取71例于天津医科大学总医院行早期周围型肺癌根治术的患者为研究对象，根据手术方式不同分为胸腔镜组35例和开胸手术组36例，比较两组患者手术时间、出血量、淋巴结清扫个数、术后胸管留置时间、胸引量及术前1 d，术后3 d和术后7 d的C-反应蛋白（C-reactive protein, CRP）、α-肿瘤坏死因子（tumor necrosis factor-α, TNF-α）、白介素-6（interleukin-6, IL-6）、IL-10的水平。结果两组患者手术时间、出血量、淋巴结清扫个数、术后胸管留置时间、胸引量无明显差异，术后CRP、TNF-α、IL-6和IL-10的水平均较术前升高，胸腔镜组患者的升高幅度小于开胸手术组。结论胸腔镜行早期周围型肺癌根治术对患者机体术后炎性反应状态影响更小。
배경여목적흉강경치료조기폐암재예후방면취득여전통개흉수술방식상동적효과，환자재저량충술식술후회복방면시부존재차별시최근연구적열점。본연구지재탐토흉강경치료조기주위형폐암근치술환자궤체술후염성상태변화。방법선취71례우천진의과대학총의원행조기주위형폐암근치술적환자위연구대상，근거수술방식불동분위흉강경조35례화개흉수술조36례，비교량조환자수술시간、출혈량、림파결청소개수、술후흉관류치시간、흉인량급술전1 d，술후3 d화술후7 d적C-반응단백（C-reactive protein, CRP）、α-종류배사인자（tumor necrosis factor-α, TNF-α）、백개소-6（interleukin-6, IL-6）、IL-10적수평。결과량조환자수술시간、출혈량、림파결청소개수、술후흉관류치시간、흉인량무명현차이，술후CRP、TNF-α、IL-6화IL-10적수평균교술전승고，흉강경조환자적승고폭도소우개흉수술조。결론흉강경행조기주위형폐암근치술대환자궤체술후염성반응상태영향경소。
Background and objective It has been proven that video assited thoracoscopic surgery (VATS) achieved the same survival rates compared with traditional open chest operation in the treatment of early stage of lung cancer. but it is unclear if there is any difference of body inlfammatory reaction between the two operation. hTe aim of this study is to investigate the changes of inlfammatory state of thoracoscopic radical lobectomy in early peripheral lung cancer patients. Meth-ods Senventy-one early peripheral lung cancer patients who have underwent radical lobectomy were divided into two groups based on the different operation method. hTe VATS group was treated by thoracoscopic lobectomy. hTe thoracotomy group was treated by traditional thoracotomy. hTen the level of serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), in-terleukin-6 (IL-6) and IL-10 at 1-day before operation and 3-day, 7-day postoperation were measured and compared between the two groups. Results No signiifcant difference was found in the level of serum CRP, TNF-α, IL-6 and IL-10 before opera-tion. Compared to the thoracotomy group, the level of serum CRP, TNF-α, IL-6 and IL-10 in the VATS group were signiifcant-ly lower atfer operation. Conclusion Compared with thoracotomy lobectomy, thoracoscopic lobectomy for early peripheral lung cancer patients is associated with lower inlfammatory responses .