国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
20期
65-67
,共3页
全麻拔管期%丙泊酚%靶控输注
全痳拔管期%丙泊酚%靶控輸註
전마발관기%병박분%파공수주
Extubating period of general anesthesia%Propofoi%Target controlled infusion
目的 研究丙泊酚靶控输注(TCI)在全麻拔管期间预防心血管反应的有效性和可行性.方法 选择ASA Ⅰ～Ⅱ级择期行腹部手术患者60例,随机分为丙泊酚组(A组)和对照组(B组).在拔管条件相同情况下,A组患者行丙泊酚TCI,Marsh模型,血浆靶浓度为1μg/ml,至气管拔管后5min停药;B组不给药,吸痰后拔管.术中连续监测呼吸频率、心率、MAP、SpO2;TCI开始前,吸痰时.拔管时,拔管后5min,10min的呼吸频率、心率、MAP、SpO2及患者的呼吸恢复时间、拔管时间、清醒程度、不良反应等情况.结果 A组吸痰时,拔管时,拔管后5min,10min的呼吸频率、心率、MAP较TCI开始前有稍许下降,且A组明显低于B组(P<0.05),B组吸痰时,拔管时SpO2明显低于基础值(P<0.05).结论 丙泊酚靶控输注用于全麻拔管期,机体应激反应小,拔管过程中生命体征平稳.
目的 研究丙泊酚靶控輸註(TCI)在全痳拔管期間預防心血管反應的有效性和可行性.方法 選擇ASA Ⅰ～Ⅱ級擇期行腹部手術患者60例,隨機分為丙泊酚組(A組)和對照組(B組).在拔管條件相同情況下,A組患者行丙泊酚TCI,Marsh模型,血漿靶濃度為1μg/ml,至氣管拔管後5min停藥;B組不給藥,吸痰後拔管.術中連續鑑測呼吸頻率、心率、MAP、SpO2;TCI開始前,吸痰時.拔管時,拔管後5min,10min的呼吸頻率、心率、MAP、SpO2及患者的呼吸恢複時間、拔管時間、清醒程度、不良反應等情況.結果 A組吸痰時,拔管時,拔管後5min,10min的呼吸頻率、心率、MAP較TCI開始前有稍許下降,且A組明顯低于B組(P<0.05),B組吸痰時,拔管時SpO2明顯低于基礎值(P<0.05).結論 丙泊酚靶控輸註用于全痳拔管期,機體應激反應小,拔管過程中生命體徵平穩.
목적 연구병박분파공수주(TCI)재전마발관기간예방심혈관반응적유효성화가행성.방법 선택ASA Ⅰ～Ⅱ급택기행복부수술환자60례,수궤분위병박분조(A조)화대조조(B조).재발관조건상동정황하,A조환자행병박분TCI,Marsh모형,혈장파농도위1μg/ml,지기관발관후5min정약;B조불급약,흡담후발관.술중련속감측호흡빈솔、심솔、MAP、SpO2;TCI개시전,흡담시.발관시,발관후5min,10min적호흡빈솔、심솔、MAP、SpO2급환자적호흡회복시간、발관시간、청성정도、불량반응등정황.결과 A조흡담시,발관시,발관후5min,10min적호흡빈솔、심솔、MAP교TCI개시전유초허하강,차A조명현저우B조(P<0.05),B조흡담시,발관시SpO2명현저우기출치(P<0.05).결론 병박분파공수주용우전마발관기,궤체응격반응소,발관과정중생명체정평은.
Objective To study the effectiveness and feasibility of the propofol target-controlled infusion (TCI) in the extubating period of general anesthesia to prevent cardiovascular response.Methods 60 patients who were in the ASA Ⅰ～Ⅱclass and seleetived abdominal surgery were randomly divided into the Propefol group (A) and the control group (B).Extubating in the same eircumstanees and conditions, A group were given with propofol TCI, Marsh model, keep the target plasma concentration as 1μ g/ml. and the drug withdrawal was 5rain after extubating; B group was not given the Propofol TCI,they were extubated after the sputum aspiration.The breathing rate, heart rate, MAP and SpO2 were continuous monitoring in the intraoperative, before using the TCI,during the extubating, 5min and 10min after extubatiug.And the time to recover the breathing, the time for extubating, the conscious level, the adverse effect and so on were also monitoring.Results during the extuhating, 5rain and 10min after the extubating, the breathing rate, the heart rate, MAP were declined slightly than that before using the TCI.And there was significantly lower in the A group than the B group (P < 0.05), B group, The value of SpO2 was significantly lower than the basis of value during extubating and the sputum aspiration(P < 0.05).Conclusions Propofol target-controlled infusion using in the extubating period of general anesthesia, the stress reaction of the body was small,and the vital signs were stable in the process of extubating.
