中国老年保健医学
中國老年保健醫學
중국노년보건의학
CHINESE JOURNAL OF GERIATRIC CARE
2014年
5期
7-8,9
,共3页
糖化血红蛋白%血清糖化白蛋白%空腹血糖%糖尿病%ROC曲线%联合诊断
糖化血紅蛋白%血清糖化白蛋白%空腹血糖%糖尿病%ROC麯線%聯閤診斷
당화혈홍단백%혈청당화백단백%공복혈당%당뇨병%ROC곡선%연합진단
Glycosylated hemoglobin%Glycated serum albumin%Fasting plasma glucose%Diabetes mellitus%ROC curve%Combined diagnosis
目的：评估糖化血红蛋白（HbA1c）、血清糖化白蛋白（Glycated Albumin，GA）及空腹血糖（Fasting Plasma Glucose， FPG）在糖尿病（ Diabetes Mellitus，DM）患者早期诊断中的价值。方法收集2010～2013年浙江省台州医院同时检测HbA1c、GA及FPG的人群的相关数据，分为糖尿病组和非糖尿病组，进行受试者工作特征曲线（ Receiver Operator Character-istic curve，ROC曲线）分析以得出3种指标诊断DM的cut-off值、曲线下面积（ Area Under the Curve，AUC）其灵敏度、特异性，再进一步计算3种指标联合诊断DM的灵敏度及特异性。结果①DM组的HbA1c、GA及FPG均高于非DM 组（ HbA1c：9．14％vs．5．84％， P ＝0．000；GA：24．8mmol/Lvs．13．8mmol/L， P ＝0．000；FPG：9．65mmol/L vs．5．77mmol/L， P ＝0．000）。②HbA1c诊断DM的cut-off值为6．85％，AUC为0．911，灵敏度为84．2％，特异性为96．2％；GA诊断DM的cut-off值为17．5，AUC为0．881，灵敏度为71．6％，特异性为93．6％；FPG诊断DM的cut-off值为7．52mmol/L，AUC为0．836，灵敏度为70．2％，特异性为82．1％。③HbA1c、GA及FPG联合诊断DM的灵敏度及特异性分别为91．1％，76．3％。结论HbA1c、GA及FPG对DM皆有诊断价值，其中HbA1c的诊断DM效能最大。 HbA1c、GA及FPG联合诊断可提高DM诊断的灵敏度，在DM筛查中具有重要价值。
目的：評估糖化血紅蛋白（HbA1c）、血清糖化白蛋白（Glycated Albumin，GA）及空腹血糖（Fasting Plasma Glucose， FPG）在糖尿病（ Diabetes Mellitus，DM）患者早期診斷中的價值。方法收集2010～2013年浙江省檯州醫院同時檢測HbA1c、GA及FPG的人群的相關數據，分為糖尿病組和非糖尿病組，進行受試者工作特徵麯線（ Receiver Operator Character-istic curve，ROC麯線）分析以得齣3種指標診斷DM的cut-off值、麯線下麵積（ Area Under the Curve，AUC）其靈敏度、特異性，再進一步計算3種指標聯閤診斷DM的靈敏度及特異性。結果①DM組的HbA1c、GA及FPG均高于非DM 組（ HbA1c：9．14％vs．5．84％， P ＝0．000；GA：24．8mmol/Lvs．13．8mmol/L， P ＝0．000；FPG：9．65mmol/L vs．5．77mmol/L， P ＝0．000）。②HbA1c診斷DM的cut-off值為6．85％，AUC為0．911，靈敏度為84．2％，特異性為96．2％；GA診斷DM的cut-off值為17．5，AUC為0．881，靈敏度為71．6％，特異性為93．6％；FPG診斷DM的cut-off值為7．52mmol/L，AUC為0．836，靈敏度為70．2％，特異性為82．1％。③HbA1c、GA及FPG聯閤診斷DM的靈敏度及特異性分彆為91．1％，76．3％。結論HbA1c、GA及FPG對DM皆有診斷價值，其中HbA1c的診斷DM效能最大。 HbA1c、GA及FPG聯閤診斷可提高DM診斷的靈敏度，在DM篩查中具有重要價值。
목적：평고당화혈홍단백（HbA1c）、혈청당화백단백（Glycated Albumin，GA）급공복혈당（Fasting Plasma Glucose， FPG）재당뇨병（ Diabetes Mellitus，DM）환자조기진단중적개치。방법수집2010～2013년절강성태주의원동시검측HbA1c、GA급FPG적인군적상관수거，분위당뇨병조화비당뇨병조，진행수시자공작특정곡선（ Receiver Operator Character-istic curve，ROC곡선）분석이득출3충지표진단DM적cut-off치、곡선하면적（ Area Under the Curve，AUC）기령민도、특이성，재진일보계산3충지표연합진단DM적령민도급특이성。결과①DM조적HbA1c、GA급FPG균고우비DM 조（ HbA1c：9．14％vs．5．84％， P ＝0．000；GA：24．8mmol/Lvs．13．8mmol/L， P ＝0．000；FPG：9．65mmol/L vs．5．77mmol/L， P ＝0．000）。②HbA1c진단DM적cut-off치위6．85％，AUC위0．911，령민도위84．2％，특이성위96．2％；GA진단DM적cut-off치위17．5，AUC위0．881，령민도위71．6％，특이성위93．6％；FPG진단DM적cut-off치위7．52mmol/L，AUC위0．836，령민도위70．2％，특이성위82．1％。③HbA1c、GA급FPG연합진단DM적령민도급특이성분별위91．1％，76．3％。결론HbA1c、GA급FPG대DM개유진단개치，기중HbA1c적진단DM효능최대。 HbA1c、GA급FPG연합진단가제고DM진단적령민도，재DM사사중구유중요개치。
Objectives To assess the diagnostic value of glycated hemoglobin ( HbA1c) ,serum glycated albumin ( Glycated Al-bumin,GA) and fasting plasma glucose ( Fasting Plasma Glucose,FPG) to early diabetes ( Diabetes Mellitus ,DM) patients.Methods Patients who came to Taizhou Hospital of Zhejiang Provinceduring 2010~2013 and detected HbA1c,GA and FPG simultaneously were collected.The crowd were divided into diabetic group and non-diabetic group for the receiver operating characteristic curve ( Re-ceiver Operator Characteristic curve,ROC curves ) analysis.The cut-off value ,area under the curve( AUC) ,sensitivity and specifici-ty were calculated,the combined diagnostic sensitivity and specificity of HbA1c,GA and FPG were further analyzed.Results ①HbA1c,GA and FPG were higher in DM group than the non-DM group (HbA1c:9.14%vs.5.84%,P=0.000;GA:24.8mmol/L vs.13.8mmol/L,P=0.000;FPG:9.65mmol/L vs .5.77mmol/L,P=0.000).②The cut-off value ,AUC,sensitivity and speci-ficity of HbA1c in diagnosis of DM were 6.85%,0.911,84.2%,96.2%,respectively;The cut-off value ,AUC,sensitivity and spe-cificity of GA in diagnosis of DM were 17.5mmol/L,0.881,71.6%,93.6%,respectively;The cut-off value ,AUC,sensitivity and specificity of FPG in diagnosis of DM were 7.52mmol/L,0.836,70.2%,82.1%,respectively.③The combined sensitivity and spe-cificity of HbA1c,GA and FPG in diagnosing DM was 91.1%and 76.3%.Conclusions HbA1c,GA and FPG had diagnostic val-ue for DM individually,among the three,HbA1c had the maximum diagnostic performance.HbA1c,GA and FPG could be combined to improve the sensitivity in DM diagnosis,with important value in screening DM.
