CAJ | 학술논문

复发性阿弗他溃疡（ Recurrent Aphthous Ulcer，RAU）又称复发性口腔溃疡，患病率居口腔黏膜疾病之首，患者痛疼剧烈，严重影响生活质量，具有复发性、周期性、自限性等特点。关于RAU的病因，早期有研究者曾报道在RAU病灶中分离提取出单纯疱疹病毒，稍后又发现RAU的发病与内分泌因素、神经精神因素、放射治疗以及VitB12缺乏等有关。还有研究则指出，RAU的发病与细胞免疫和体液免疫有关，是对口腔上皮细胞或微生物交叉抗原刺激所发生的一种自身免疫性疾病。近年来，在针对口腔黏膜病的进一步研究中，许多学者注意到口腔黏膜所存在的环境，认为口腔幽门螺杆菌与RAU的发病有关。
복발성아불타궤양（ Recurrent Aphthous Ulcer，RAU）우칭복발성구강궤양，환병솔거구강점막질병지수，환자통동극렬，엄중영향생활질량，구유복발성、주기성、자한성등특점。관우RAU적병인，조기유연구자증보도재RAU병조중분리제취출단순포진병독，초후우발현RAU적발병여내분비인소、신경정신인소、방사치료이급VitB12결핍등유관。환유연구칙지출，RAU적발병여세포면역화체액면역유관，시대구강상피세포혹미생물교차항원자격소발생적일충자신면역성질병。근년래，재침대구강점막병적진일보연구중，허다학자주의도구강점막소존재적배경，인위구강유문라간균여RAU적발병유관。
Recurrent aphthous ulcer is also known as recurrent oral ulcer,which is at the top of morbidity in the oral mucosal dis-eases,with periodicity and recurrence and restriction.The severe pain seriously affect the quality of life.The early research about the etiology of recurrent aphthous ulcer discovered and isolated the HSV form the lesions area in RAU,and supported it associated with psychological factors、endocrine factors、radiotherapy and the shortages of VitB12 and so on[1] .Later researches point out the course of RAU involved in cell -mediated immunity and humoral immunity,which are autoimmune diseases resulted from the cross-antigen stimulation of oral epithelial cells or microorganisms.Currently,the oral mucosa environment is concerned in further study of oral mu-cosal disease,which is associated with Oral Helicobacter pylori[2] .