心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2014年
5期
550-552
,共3页
冠状动脉疾病%动脉硬化%白细胞介素8
冠狀動脈疾病%動脈硬化%白細胞介素8
관상동맥질병%동맥경화%백세포개소8
Coronary artery disease%Atherosclerosis%Interleukin-8
目的:探讨冠心病患者介入治疗后白介素(IL)-8和C反应蛋白(CRP)水平变化。方法:入选2010年3月~2012年12月在本院住院治疗的冠心病患者共90例,根据治疗方法分为 PCI组(70例),保守治疗组(20例),另选择20例健康人群作为健康对照组。比较治疗前,治疗后20d内IL-8和CRP含量的变化。结果:与治疗前比较,治疗后1d PCI组IL-8[(63.22±13.10) pg/ml比(31.58±9.10) pg/ml]、CRP [(14.59±6.13) mg/L比(9.61±2.35) mg/L]水平显著下降,且IL-8明显低于保守治疗组[(50.18±19.31) pg/ml], P<0.01;20d后,PCI组IL-8[(15.13±5.22) pg/ml]、CRP [(3.01±0.76) mg/L]水平下降更加显著(P<0.05~<0.01),且显著低于保守治疗组[(27.22±14.69) pg/ml ,(5.46±2.77) mg/L], P均<0.01,甚至PCI组的IL-8水平与健康对照组[(15.58±4.10) pg/ml]无明显差异(P>0.05)。结论:PCI术后白介素-8和C反应蛋白水平明显下降,可作为评估冠心病合并动脉粥样硬化患者PCI术后预后的指标。
目的:探討冠心病患者介入治療後白介素(IL)-8和C反應蛋白(CRP)水平變化。方法:入選2010年3月~2012年12月在本院住院治療的冠心病患者共90例,根據治療方法分為 PCI組(70例),保守治療組(20例),另選擇20例健康人群作為健康對照組。比較治療前,治療後20d內IL-8和CRP含量的變化。結果:與治療前比較,治療後1d PCI組IL-8[(63.22±13.10) pg/ml比(31.58±9.10) pg/ml]、CRP [(14.59±6.13) mg/L比(9.61±2.35) mg/L]水平顯著下降,且IL-8明顯低于保守治療組[(50.18±19.31) pg/ml], P<0.01;20d後,PCI組IL-8[(15.13±5.22) pg/ml]、CRP [(3.01±0.76) mg/L]水平下降更加顯著(P<0.05~<0.01),且顯著低于保守治療組[(27.22±14.69) pg/ml ,(5.46±2.77) mg/L], P均<0.01,甚至PCI組的IL-8水平與健康對照組[(15.58±4.10) pg/ml]無明顯差異(P>0.05)。結論:PCI術後白介素-8和C反應蛋白水平明顯下降,可作為評估冠心病閤併動脈粥樣硬化患者PCI術後預後的指標。
목적:탐토관심병환자개입치료후백개소(IL)-8화C반응단백(CRP)수평변화。방법:입선2010년3월~2012년12월재본원주원치료적관심병환자공90례,근거치료방법분위 PCI조(70례),보수치료조(20례),령선택20례건강인군작위건강대조조。비교치료전,치료후20d내IL-8화CRP함량적변화。결과:여치료전비교,치료후1d PCI조IL-8[(63.22±13.10) pg/ml비(31.58±9.10) pg/ml]、CRP [(14.59±6.13) mg/L비(9.61±2.35) mg/L]수평현저하강,차IL-8명현저우보수치료조[(50.18±19.31) pg/ml], P<0.01;20d후,PCI조IL-8[(15.13±5.22) pg/ml]、CRP [(3.01±0.76) mg/L]수평하강경가현저(P<0.05~<0.01),차현저저우보수치료조[(27.22±14.69) pg/ml ,(5.46±2.77) mg/L], P균<0.01,심지PCI조적IL-8수평여건강대조조[(15.58±4.10) pg/ml]무명현차이(P>0.05)。결론:PCI술후백개소-8화C반응단백수평명현하강,가작위평고관심병합병동맥죽양경화환자PCI술후예후적지표。
Objective:To explore interleukin (IL)-8 and C reactive protein (CRP) levels change after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) .Methods :A total of 90 CHD patients , who hospitalized in our hospital from Mar 2010 to Dec 2012 ,were selected .According to their therapeutic methods , they were divided into PCI group (n=70) and conservative treatment group (n=20) .Another 20 healthy people were regarded as healthy control group .Changes of IL-8 and C reactive protein (CRP ) concentrations before and within 20d after treatment were compared among three groups .Results :Compared with before treatment ,on 1d af-ter treatment ,there were significant reductions in levels of IL-8 [ (63.22 ± 13.10) pg/ml vs .(31.58 ± 9.10) pg/ml] and CRP [ (14.59 ± 6.13) mg/L vs .(9.61 ± 2.35) mg/L] in PCI group ,IL-8 was significantly lower than that of conservative treatment group [(50.18 ± 19.31) pg/ml] ,P<0.01 ;after 20d ,levels of IL-8 [(15.13 ± 5.22) pg/ml] and CRP [ (3.01 ± 0.76) mg/L] further declined in PCI group (P<0.05~ <0.01) ,and they were significantly lower than those of conservative treatment group [ (27.22 ± 14.69) pg/ml ,(5.46 ± 2.77) mg/L] , P<0.01 all , e-ven the IL-8 level of PCI group was not significant different from that of healthy control group [ (15.58 ± 4.10) pg/ml] , P>0.05. Conclusion:IL-8 and C reactive protein levels significantly reduce after PCI ,which can be treated as indexes evaluating PCI postoperative prognosis in CHD patients .