心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2014年
5期
544-545,546
,共3页
王宇平%郭金成%张铭%张海滨%张学坤%甘舜进%高国旺%张立新%张正海%蔡宜婷%唐宇%柳子静
王宇平%郭金成%張銘%張海濱%張學坤%甘舜進%高國旺%張立新%張正海%蔡宜婷%唐宇%柳子靜
왕우평%곽금성%장명%장해빈%장학곤%감순진%고국왕%장립신%장정해%채의정%당우%류자정
心肌梗塞%血小板聚集%比伐卢定
心肌梗塞%血小闆聚集%比伐盧定
심기경새%혈소판취집%비벌로정
Myocardial infarction%Platelet aggregation%Bivalirudin
目的：探讨国产比伐卢定在急诊经皮冠状动脉介入治疗（PCI）中对血小板功能的影响。方法：100例急性ST段抬高性心肌梗死接受急诊PCI的患者随机分为肝素组（53例）和比伐卢定组（47例）。检测两组 PCI术前后二磷酸腺苷（ADP）诱导的血小板聚集率，并进行统计学比较。结果：急诊PCI术前，两组 ADP诱导的血小板凝聚率差异无统计学意义（ P＝0.99）。急诊 PCI术后，比伐卢定组 ADP 诱导的血小板凝聚率显著低于肝素组[（16.46±10.23）％比（25.21±15.91）％， P＜0.01]。结论：PCI术中，与常规肝素抗凝相比，作为抗凝剂的比伐卢定可以更明显抑制血小板凝聚，具有抗血小板的功能。
目的：探討國產比伐盧定在急診經皮冠狀動脈介入治療（PCI）中對血小闆功能的影響。方法：100例急性ST段抬高性心肌梗死接受急診PCI的患者隨機分為肝素組（53例）和比伐盧定組（47例）。檢測兩組 PCI術前後二燐痠腺苷（ADP）誘導的血小闆聚集率，併進行統計學比較。結果：急診PCI術前，兩組 ADP誘導的血小闆凝聚率差異無統計學意義（ P＝0.99）。急診 PCI術後，比伐盧定組 ADP 誘導的血小闆凝聚率顯著低于肝素組[（16.46±10.23）％比（25.21±15.91）％， P＜0.01]。結論：PCI術中，與常規肝素抗凝相比，作為抗凝劑的比伐盧定可以更明顯抑製血小闆凝聚，具有抗血小闆的功能。
목적：탐토국산비벌로정재급진경피관상동맥개입치료（PCI）중대혈소판공능적영향。방법：100례급성ST단태고성심기경사접수급진PCI적환자수궤분위간소조（53례）화비벌로정조（47례）。검측량조 PCI술전후이린산선감（ADP）유도적혈소판취집솔，병진행통계학비교。결과：급진PCI술전，량조 ADP유도적혈소판응취솔차이무통계학의의（ P＝0.99）。급진 PCI술후，비벌로정조 ADP 유도적혈소판응취솔현저저우간소조[（16.46±10.23）％비（25.21±15.91）％， P＜0.01]。결론：PCI술중，여상규간소항응상비，작위항응제적비벌로정가이경명현억제혈소판응취，구유항혈소판적공능。
Objective:To explore the impact of domestic bivalirudin on platelet function during emergency percutane-ous coronary intervention (PCI) .Methods :A total of 100 patients with acute ST segment elevation myocardial in-farction who recieved emergency PCI were randomly divided into unfractionated heparin group (UFH group ,n=53) and bivalirudin group (n=47) .Adenyl diphosphoric acid (ADP)-induced platelet aggregation rate was meas-ured and statistically compared between two groups before and after PCI .Results:Before emergency PCI ,there was no significant difference in ADP-induced platelet aggregation rate between two groups (P=0.99) .After emergency PCI ,ADP-induced platelet aggregation rate in bivalirudin group was significantly lower than that of UFH group [ (16.46 ± 10.23)% vs .(25.21 ± 15.91) % , P<0.01] .Conclusion:During percutaneous coronary intervention , compared with routine heparin anticoagulation , bivalirudin , as an anticoagulant , can more significantly inhibit platelet aggregation and possess antiplatelet effect .
