中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
25期
4020-4025
,共6页
生物材料%口腔生物材料%上颌窦提升%引导骨再生%牙种植%生物膜%骨形成%广东省自然科学基金
生物材料%口腔生物材料%上頜竇提升%引導骨再生%牙種植%生物膜%骨形成%廣東省自然科學基金
생물재료%구강생물재료%상합두제승%인도골재생%아충식%생물막%골형성%광동성자연과학기금
maxilary sinus%bone regeneration%dental implantation%biofilms
背景：利用生物膜引导骨再生技术在上颌窦提升中成骨是牙种植的研究热点。目的：探讨引导骨再生技术在上颌窦提升中的成骨效果。方法：9只比格犬进行双侧上颌窦底提升同期牙种植，实验侧行胶原膜覆盖颊侧创口，对照侧无胶原膜覆盖。术后4，12，24周分别处死实验犬，行大体标本、力学测试及组织学检查。结果与结论：术后12，24周时对照侧骨移植材料有移位，骨质吸收明显，种植体顶部暴露，实验侧种植体顶部骨移植材料无移位现象，有较厚的骨质覆盖。随时间的增加，种植体牵出力增加，在24周时实验侧与对照侧差异有显著性意义(P <0.05)。组织学检查可见双侧上颌窦底植入骨粉后均可见新生骨形成，随时间延长逐渐增多、成熟，骨粉颗粒逐渐减少，术后12，24周时实验组与对照组新生骨的面积比较差异有显著性意义(P <0.05)。结果显示生物膜引导再生技术可减少上颌窦提升后骨的吸收，促进新骨骨形成。
揹景：利用生物膜引導骨再生技術在上頜竇提升中成骨是牙種植的研究熱點。目的：探討引導骨再生技術在上頜竇提升中的成骨效果。方法：9隻比格犬進行雙側上頜竇底提升同期牙種植，實驗側行膠原膜覆蓋頰側創口，對照側無膠原膜覆蓋。術後4，12，24週分彆處死實驗犬，行大體標本、力學測試及組織學檢查。結果與結論：術後12，24週時對照側骨移植材料有移位，骨質吸收明顯，種植體頂部暴露，實驗側種植體頂部骨移植材料無移位現象，有較厚的骨質覆蓋。隨時間的增加，種植體牽齣力增加，在24週時實驗側與對照側差異有顯著性意義(P <0.05)。組織學檢查可見雙側上頜竇底植入骨粉後均可見新生骨形成，隨時間延長逐漸增多、成熟，骨粉顆粒逐漸減少，術後12，24週時實驗組與對照組新生骨的麵積比較差異有顯著性意義(P <0.05)。結果顯示生物膜引導再生技術可減少上頜竇提升後骨的吸收，促進新骨骨形成。
배경：이용생물막인도골재생기술재상합두제승중성골시아충식적연구열점。목적：탐토인도골재생기술재상합두제승중적성골효과。방법：9지비격견진행쌍측상합두저제승동기아충식，실험측행효원막복개협측창구，대조측무효원막복개。술후4，12，24주분별처사실험견，행대체표본、역학측시급조직학검사。결과여결론：술후12，24주시대조측골이식재료유이위，골질흡수명현，충식체정부폭로，실험측충식체정부골이식재료무이위현상，유교후적골질복개。수시간적증가，충식체견출력증가，재24주시실험측여대조측차이유현저성의의(P <0.05)。조직학검사가견쌍측상합두저식입골분후균가견신생골형성，수시간연장축점증다、성숙，골분과립축점감소，술후12，24주시실험조여대조조신생골적면적비교차이유현저성의의(P <0.05)。결과현시생물막인도재생기술가감소상합두제승후골적흡수，촉진신골골형성。
BACKGROUND:The use of bio-membrane guided bone regeneration in maxilary sinus augmentation is a research hotspot in implantology at present. OBJECTIVE:To investigate the osteogenic effect of guided bone regeneration in maxilary sinus augmentation using colagen membranes. METHODS:The first maxilary molars of nine adult female beagle dogs were extracted and ful-thickness flap was reflected bilateraly, then the sinus floors were lifted with simultaneous implantation. Bio-Oss was placed into the new space under the sinus membrane. On the experimental side in each dog, the bio-membrane covered the osteotomy window. On the control side, the flap was sutured directly, and was not covered by bio-membrane. Two animals were sacrificed at 4, 12, and 24 weeks after surgery, respectively. Gross observation, biomechanical testing and histological examinations were performed. RESULTS AND CONCLUSION: In gross view, new bone formation was observed in al maxilary sinuses. The pul-out force increased with time. At week 24, a significant difference in the pul-out force was noted between the two groups (P < 0.05). Histomorphbomatrical analysis showed much more new caluses at the experimental group than the control group at weeks 12 and 24 after surgery (P < 0.05). The bio-membrane guided bone regeneration has a better effect on new bone formation in the sinus augmentation.
