世界最新医学信息文摘（电子版）
世界最新醫學信息文摘（電子版）
세계최신의학신식문적（전자판）
World Latest Medicine Information
2014年
21期
26-27
,共2页
Ⅱ型糖尿病合并重症%甘精胰岛素%短效胰岛素%联合用药%强化治疗
Ⅱ型糖尿病閤併重癥%甘精胰島素%短效胰島素%聯閤用藥%彊化治療
Ⅱ형당뇨병합병중증%감정이도소%단효이도소%연합용약%강화치료
type ii diabetes mellitus complicated with severe%insulin glargine%insulin%combination therapy%treatment
目的：观察甘精胰岛素联合短效胰岛素治疗Ⅱ型糖尿病合并内科重症患者的有效性和安全性。方法Ⅱ型糖尿合并内科重症患者128例，男性85例，女性43例，年龄38～72岁，平均年龄49.32岁。随机分为两组，各64例。对照组给予预混胰岛素皮下注射；治疗组给予甘精胰岛素加短效胰岛素皮下注射。住院期间观察10～15天，出院后随访3个月。观察病情改善情况、空腹血糖、餐后2小时血糖、糖化血红蛋白（Hba1c）、每日血糖波动差值、低血糖发生率等指标。结果两组治疗后，观察组空腹血糖、早餐及午餐后2小时血糖控制方面明显优于对照组；每日间血糖波动差值明显小于对照组。但晚餐后2小时血糖两组间无明显差异。观察两组低血糖发生率观察组（4.7％），优于对照组（22.3％）。观察组病情缓解情况明显优于对照组。结论甘精胰岛素联合短效胰岛素强化治疗Ⅱ型糖尿病合并内科重症患者疗效显著。能有效控制空腹及餐后血糖，减少每日血糖波动，低血糖发生率低，加快病情缓解，是一种安全、有效的治疗方法。
目的：觀察甘精胰島素聯閤短效胰島素治療Ⅱ型糖尿病閤併內科重癥患者的有效性和安全性。方法Ⅱ型糖尿閤併內科重癥患者128例，男性85例，女性43例，年齡38～72歲，平均年齡49.32歲。隨機分為兩組，各64例。對照組給予預混胰島素皮下註射；治療組給予甘精胰島素加短效胰島素皮下註射。住院期間觀察10～15天，齣院後隨訪3箇月。觀察病情改善情況、空腹血糖、餐後2小時血糖、糖化血紅蛋白（Hba1c）、每日血糖波動差值、低血糖髮生率等指標。結果兩組治療後，觀察組空腹血糖、早餐及午餐後2小時血糖控製方麵明顯優于對照組；每日間血糖波動差值明顯小于對照組。但晚餐後2小時血糖兩組間無明顯差異。觀察兩組低血糖髮生率觀察組（4.7％），優于對照組（22.3％）。觀察組病情緩解情況明顯優于對照組。結論甘精胰島素聯閤短效胰島素彊化治療Ⅱ型糖尿病閤併內科重癥患者療效顯著。能有效控製空腹及餐後血糖，減少每日血糖波動，低血糖髮生率低，加快病情緩解，是一種安全、有效的治療方法。
목적：관찰감정이도소연합단효이도소치료Ⅱ형당뇨병합병내과중증환자적유효성화안전성。방법Ⅱ형당뇨합병내과중증환자128례，남성85례，녀성43례，년령38～72세，평균년령49.32세。수궤분위량조，각64례。대조조급여예혼이도소피하주사；치료조급여감정이도소가단효이도소피하주사。주원기간관찰10～15천，출원후수방3개월。관찰병정개선정황、공복혈당、찬후2소시혈당、당화혈홍단백（Hba1c）、매일혈당파동차치、저혈당발생솔등지표。결과량조치료후，관찰조공복혈당、조찬급오찬후2소시혈당공제방면명현우우대조조；매일간혈당파동차치명현소우대조조。단만찬후2소시혈당량조간무명현차이。관찰량조저혈당발생솔관찰조（4.7％），우우대조조（22.3％）。관찰조병정완해정황명현우우대조조。결론감정이도소연합단효이도소강화치료Ⅱ형당뇨병합병내과중증환자료효현저。능유효공제공복급찬후혈당，감소매일혈당파동，저혈당발생솔저，가쾌병정완해，시일충안전、유효적치료방법。
objective to observe the effect of Gan efficacy and safety in patients with insulin glargine combined with short acting insulin therapy in type Ⅱ diabetes mellitus patients in department of internal medicine. Methods 128 cases of type II diabetes and Department of internal medicine of critically ill patients, male 85 cases, female 43 cases, age 38 ~ 72 years old, the average age is 49.32 years old. Were randomly divided into two groups, 64 cases in each. the control group was given the premixed subcutaneous insulin injection; treatment group were given insulin glargine combined with short acting insulin subcutaneous injection. During hospitalization were observed in 10 ~ 15 days, after 3 months of follow-up. Observe the condition to improve the situation, fasting blood glucose, postprandial 2 hour blood glucose, glycosylated hemoglobin (HbA1c), the fluctuation of blood glucose difference, incidence of hypoglycemic episodes. Results of the two groups after treatment, blood glucose, breakfast and lunch group after 2 hours fasting blood glucose control is superior to the control group;the difference between the daily fluctuation of blood glucose was significantly less than the control group. But after dinner 2 hours blood glucose was not different between the two groups. observation of the two groups the incidence of hypoglycemia in observation group (4.7%), better than the control group (22.3%). the observation group was better than control group in remission. Conclusion insulin glargine combined with short acting insulin intensive treatment of type ii diabetes patients complicated with severe department of internal medicine curative effect. can effectively control the fasting and postprandial blood glucose, reduce the fluctuation of blood glucose, hypoglycemia, accelerate the remission of the disease, is a safe, effective method for the treatment of.
