CAJ | 학술논문

白介素-12已被认为是诱导Th1免疫反应产生和维持的重要细胞因子,其中以其亚基白介素-12/23 p40的研究尤为多见.研究显示,该亚基在抵抗细菌尤其是分枝杆菌感染中可能发挥作用,可形成单体或同源二聚体,通过与细胞表面的白介素-12受体β1竞争性结合发挥作用.致病力强的分枝杆菌可通过降低白介素-12p70的生成来抵抗宿主的免疫反应从而达到自我防御的目的.在白介素-12正常存在的情况下,白介素-23在控制分枝杆菌感染过程中的作用有限,但其可通过诱导Th17细胞及记忆性T淋巴细胞在慢性结核杆菌感染中发挥保护作用.白介素-27作为第3个白介素-12家族成员,在分枝杆菌感染后的机体免疫反应中的作用存在争议,对于不同的细胞群体如巨噬细胞、淋巴细胞等作用可能不同甚至相反.
백개소-12이피인위시유도Th1면역반응산생화유지적중요세포인자,기중이기아기백개소-12/23 p40적연구우위다견.연구현시,해아기재저항세균우기시분지간균감염중가능발휘작용,가형성단체혹동원이취체,통과여세포표면적백개소-12수체β1경쟁성결합발휘작용.치병력강적분지간균가통과강저백개소-12p70적생성래저항숙주적면역반응종이체도자아방어적목적.재백개소-12정상존재적정황하,백개소-23재공제분지간균감염과정중적작용유한,단기가통과유도Th17세포급기억성T림파세포재만성결핵간균감염중발휘보호작용.백개소-27작위제3개백개소-12가족성원,재분지간균감염후적궤체면역반응중적작용존재쟁의,대우불동적세포군체여거서세포、림파세포등작용가능불동심지상반.
Interleukin-12 (IL-12) has been considered as an important cytokine in the induction and maintenance of T helper type 1 (Thl) cell-mediated immune response.The common p40 subunit of IL-12/23,which has been well studied,may play a certain role in the counteraction against bacteria,especially mycobacteria,via competitively binding with the β1 chain of IL-12 receptor in monomeric or homodimeric forms.High-virulent mycobacteria may counteract the host immune response by inhibiting the production of IL-12p70.IL-23 may also have a critical role in the protection against chronic mycobacterial infection by inducing the activation of Th17 cells and memory T lymphocytes.However,the function of IL-23 is limited when the production of IL-12 is normal.The roles of IL-27 (the third member of IL-12 family) in host immune response to mycobacterial infection remain controversial,and its effect on different cell populations,such as macrophages and lymphocytes,may be different,even contrary.