延边大学学报（自然科学版）
延邊大學學報（自然科學版）
연변대학학보（자연과학판）
JOURNAL OF YANBIAN UNIVERSITY(NATURAL SCIENCE EDITION)
2014年
2期
117-120
,共4页
桦木醇%吡啶盐衍生物%MTT法%抗癌活性
樺木醇%吡啶鹽衍生物%MTT法%抗癌活性
화목순%필정염연생물%MTT법%항암활성
betulin%pyridine salt derivatives%MTT assay%anti-cancer activity
以桦木醇为原料合成了4种桦木醇吡啶盐，运用1 H-NMR 和 IR 确认了化合物的结构。用噻唑蓝（MTT）比色法对这4种化合物对肝星状细胞、人肺癌细胞和人肝癌细胞的抑制作用进行了活性分析，结果表明，化合物3、4a和4c对上述3种癌细胞有明显的抑制作用，并且对肝星状细胞的 IC50值均明显低于桦木醇。
以樺木醇為原料閤成瞭4種樺木醇吡啶鹽，運用1 H-NMR 和 IR 確認瞭化閤物的結構。用噻唑藍（MTT）比色法對這4種化閤物對肝星狀細胞、人肺癌細胞和人肝癌細胞的抑製作用進行瞭活性分析，結果錶明，化閤物3、4a和4c對上述3種癌細胞有明顯的抑製作用，併且對肝星狀細胞的 IC50值均明顯低于樺木醇。
이화목순위원료합성료4충화목순필정염，운용1 H-NMR 화 IR 학인료화합물적결구。용새서람（MTT）비색법대저4충화합물대간성상세포、인폐암세포화인간암세포적억제작용진행료활성분석，결과표명，화합물3、4a화4c대상술3충암세포유명현적억제작용，병차대간성상세포적 IC50치균명현저우화목순。
Four betulin pyridinium salts were prepared from botulin.The structure of the products were identified by 1 H-NMR and IR.In order to study the effects of betulin pyridinium salts on inhibiting tumor cells,activity analysis of compounds 3 and 4a-c on the HSC cell,A549 cell and HepG 2 was carried out by MTT assay.The results showed that compounds 3,4a and 4c had obvious inhibitory action on the HSC cell, A549 cell and HepG2.On HepG2 cells,IC50 of compounds 3,4a and 4c were significantly lower than IC50 of betulin.
