CAJ | 학술논문

目的：探讨 SOX18在胃腺癌中的表达与临床病理特征的关系，分析其在胃腺癌中的作用。方法利用免疫组织化学 SP法检测60例胃腺癌及其相应(15例)远端正常胃黏膜组织中 SOX18的表达。结果胃腺癌中 SOX18的阳性表达率为76.7%(46/60)，显著高于正常粘膜组织中的30.0%，差异具有统计学意义(P＜0.05)。胃腺癌中 SOX18蛋白的表达与肿瘤浸润深度、淋巴结转移及TNM分期有关(P＜0.05)，与患者年龄、性别、Lauren 组织学分型及肿瘤分化程度均无关(P＞0.05)。结论 SOX18在胃腺癌中的高表达可能与胃癌的发生、发展和淋巴结转移密切相关。
목적：탐토 SOX18재위선암중적표체여림상병리특정적관계，분석기재위선암중적작용。방법이용면역조직화학 SP법검측60례위선암급기상응(15례)원단정상위점막조직중 SOX18적표체。결과위선암중 SOX18적양성표체솔위76.7%(46/60)，현저고우정상점막조직중적30.0%，차이구유통계학의의(P＜0.05)。위선암중 SOX18단백적표체여종류침윤심도、림파결전이급TNM분기유관(P＜0.05)，여환자년령、성별、Lauren 조직학분형급종류분화정도균무관(P＞0.05)。결론 SOX18재위선암중적고표체가능여위암적발생、발전화림파결전이밀절상관。
Obj ective To investigate the expression of SOX1 8 in gastric adenocarcinoma and its corre-lation with clinicopathological features.Methods The expression of SOX1 8 was detected by SP immunohis-tochemical technique in 60 cases of gastric adenocarcinoma tissues and their corresponding adjacent normal gastric tissues (n=1 5 ).Results The positive percentage of SOX1 8 protein in gastric adenocarcinoma was 76.7% (46/60),which was significantly higher than that in normal gastric mucosa tissues 30.0% (P<0. 05).The expression of SOX18 was significantly related with infiltration depth,lymph node metastasis and TNM stage (P<0.05),but not with the patient's age,gender,Lauren classification and differentiation grade (P>0.05).Conclusion The high expression of SOX18 protein may play an important role in the oc-currence,development,and lymph node metastasis of gastric adenocarcinoma.